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    Xylocarpus moluccensis Fruit Fraction Rescues Cardiac Hypertrophy by Improving Angiogenesis and Regulating NF‑κB‑Mediated Inflammation

    Amit Manhas1,2, Dipika Goyal1, Bharti Biswas1, Dipti Tripathi1,2, Pragya Yadav2,3, Singh Abhinav1,2, Shri Krishna1, Narender Tadigoppula2,3, Madhu Dikshit1,2, Kumaravelu Jagavelu1,2★★ Corresponding author

    1. 1Department of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
    2. 2Academy of Science and Innovation Research, New Delhi, India
    3. 3Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, India

    CORRESPONDENCE

    Kumaravelu Jagavelu

    Principal Scientist, Pharmacology Division, CSIR-Central Drug Research Institute, CDRI/B.S.10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, India.

    kumaraveluj@cdri.res.in

    Received: 18-02-2021; Revised: 11-12-2021; Accepted: 28-01-2022.

    Volume 18, Issue 78 · pp. 286–295 · PUBLISHED 7 July 2022 · DOI: 10.4103/pm.pm_79_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background and Aim: The present study was undertaken to investigate the potential of ethyl acetate fraction obtained from the fruits of Xylocarpus moluccensis alcoholic extract (CDR‑267‑F018) against cardiac hypertrophy in rats. Experimental Procedure: Cardiac hypertrophy was achieved in Wistar rats through isoproterenol and treated either with propranolol or CDR‑267‑F018 for 14 days. Results and Conclusion: CDR‑267‑F018 treatment reduced isoproterenol induced cardiac hypertrophy as assessed by 2D‑echocardiography and supported by reduction in ANP, BNP, β‑MHC, NPP‑A and increased expression of vascular endothelial growth factor receptor 1. CDR‑267‑F018 treatment tightly regulated inflammation by controlling the plasma proinflammatory cytokines tumor necrosis factor‑α and IFN‑γ, plasma EMP level and NF‑κB, Akt and ERK. Further, CDR‑267‑F018 treatment reduced fibrosis by regulating Col18a1, FGF‑21 and MMP2. In total, CDR‑267‑F018 protected rat heart against isoproterenol induced cardiac hypertrophy by acting on inflammation, fibrosis and by improving angiogenesis.

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      Manhas, A., Goyal, D., Biswas, B., Tripathi, D., Yadav, P., Abhinav, S., Krishna, S., Tadigoppula, N., Dikshit, M., & Jagavelu, K. (2022). Xylocarpus moluccensis Fruit Fraction Rescues Cardiac Hypertrophy by Improving Angiogenesis and Regulating NF‑κB‑Mediated Inflammation. Pharmacognosy Magazine, 18(78), 286–295. https://doi.org/10.4103/pm.pm_79_21