Volume 18, Issue 78

Original Article

1. Article

   Tinospora cordifolia Ameliorates Behavioral Deficits in Conditioned Fear and Single Prolonged Stress–Induced Preclinical PTSD Model in Mice by Modulating Translocator Protein (18kDa, TSPO)

   Gaurav Ranjan, Priyashree Sunita, Pritha Bose, Sugato Banerjee, Shakti P. Pattanayak

   pp. 247–255 · DOI: 10.4103/pm.pm_89_22 · Published 7 July 2022

   Background: Post‑traumatic stress disorder (PTSD) is a severe chronic psychiatric condition for which currently there is no specific therapy. Translocator protein (18 kDa; TSPO), a critical therapeutic target for treatin…

2. Article

   Commigileadin A: A New Triterpenoid from Commiphora gileadensis Aerial Parts

   Hossam M. Abdallah, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Abdulrahman E. Koshak, Ibrahim Alnashri, Abdullah Alghamdi, Abdulghani Aljohani, Abdulrahman Khairy

   pp. 256–260 · DOI: 10.4103/pm.pm_118_21 · Published 7 July 2022

   Background: Genus Commiphora (Burseraceae) includes about 150 species of aromatic shrubs located in Africa, India, and the Arabian region. C. gileadensis L. has been used for treating several ailments such as constipatio…

3. Article

   Anti‑Inflammatory and Antiallergic Activity of Arbutin against Ovalbumin‑Induced Allergic Rhinitis in Mice through the Modulation of Inflammatory Responses

   Tao Zhang, Xiaopeng Sun, Ruiping Fang

   pp. 261–266 · DOI: 10.4103/pm.pm_14_21 · Published 7 July 2022

   Background: Allergic rhinitis (AR) is the prevalent inflammatory disease in the airway due to allergic reactions in response to numerous allergens. AR is considered as a type‑I allergic condition and proceeded as early‑ …

4. Article

   Goniothalamin‑Mediated Amelioration of Doxorubicin‑Induced Myocardial Damage and Regulation of Nuclear Factor‑κB/HO‑1/NQO‑1 Signaling Biomarkers in Cardiotoxic Rats

   Chong Liu, Qiuju Wang

   pp. 267–272 · DOI: 10.4103/pm.pm_180_21 · Published 7 July 2022

   Background: Chronic use of doxorubicin (DOX) as an anticancer and antineoplastic agent has a chief jeopardy of cardiotoxicity. About 10% of the treated population has logged to cause cardiac damage. Objectives: This stud…

5. Article

   Characterization of PLGA‑PEG Catharanthus roseus Nanoparticles and Assessing its Anticancer Effects in HER2‑Overexpressed Breast Cancer Cells

   ZS Siti, Nor Hazwani Ahmad, Shahrul Hamid

   pp. 273–280 · DOI: 10.4103/pm.pm_338_21 · Published 7 July 2022

   Background: Catharanthus roseus (CR) shows promising anticancer activity. However, there is limited information on its polymeric formulation. Objectives: Therefore, current study aimed to characterize poly(lactic‑co‑glyc…

6. Article

   Rehmanniae Radix Leaves Stimulates ROS‑Induced Apoptosis on Human Mammary Cancer Cells through Suppressing PI3K/AKT/mTOR and GSK3β Signaling Pathway

   Chao Yuan, Peihua Sun, Xin Ge, Minling Xu

   pp. 281–285 · DOI: 10.4103/pm.pm_144_21 · Published 7 July 2022

   Background: Mammary carcinoma is the most communal carcinoma of higher women mortality. Rehmanniae Radix (RR) a traditional Chinese medicine. Objectives: To examine the anti‑proliferative and anti‑apoptotic effect of RR …

7. Article

   Xylocarpus moluccensis Fruit Fraction Rescues Cardiac Hypertrophy by Improving Angiogenesis and Regulating NF‑κB‑Mediated Inflammation

   Amit Manhas, Dipika Goyal, Bharti Biswas, Dipti Tripathi, Pragya Yadav, Singh Abhinav, Shri Krishna, Narender Tadigoppula, Madhu Dikshit, Kumaravelu Jagavelu

   pp. 286–295 · DOI: 10.4103/pm.pm_79_21 · Published 7 July 2022

   Background and Aim: The present study was undertaken to investigate the potential of ethyl acetate fraction obtained from the fruits of Xylocarpus moluccensis alcoholic extract (CDR‑267‑F018) against cardiac hypertrophy …

8. Article

   Cratoxylum formosum Leaf Extracts Inhibit Growth, Induce Apoptosis, and Decrease Metastasis Of HeLa Human Cervical Cancer Cells

   Benjaporn Buranrat

   pp. 296–303 · DOI: 10.4103/pm.pm_442_21 · Published 7 July 2022

   Background: Cratoxylum formosum (CF) is being used in Asian countries to treat disease and for eating purposes. Objectives: In the present study, the young leaf extract of CF was extracted by distilled water (DW) and 95%…

9. Article

   Efficacy of Bisacurone in Bone Fracture Healing Process: An Experimental Study on Osteoporotic Rats

   Minjie Li, Weiwei Feng, Wenping Zhang, Zhonghui Pang, Shaokun Pei, Lifeng Xia, Qiang Li, Huixiao Li

   pp. 304–313 · DOI: 10.4103/pm.pm_450_21 · Published 7 July 2022

   Background: Osteoporosis (OP) is a common disorder resulting in bone fragility and fracture. Due to OP, bone mass and microarchitectural bone tissues are damaged, increasing the risk of fracture. Objectives: To determine…

10. Article

    Exploring Cross‑linked Tragacanth as Novel Excipient‑proof‑of‑concept

    Anroop B. Nair, Santosh Fattepur, N. Raghavendra Naveen, Prakash Goudanavar, Naga Prashant Koppuravuri, Buduru Gowthami, Mallikarjun Telsang, Riyaz Ali Osmani, Nagaraja Sreeharsha, Mohammed Habeebuddin

    pp. 314–320 · DOI: 10.4103/pm.pm_601_21 · Published 7 March 2022

    Background: Tragacanth, a natural gum, is frequently used as stabilizer for colloidal systems and as a binder in tablets. Materials from natural sources are in increasing demand to solve the current global environmental …

11. Article

    Preparation of a Nanoemulsified Drug Delivery System of Astilbin using Edible Formulation Components: In vivo Evaluation of Oxaliplatin‑Induced Cirrhotic Liver Injury

    Yixing Wang, Xuping Zhang, Jin Zhou, Shilei Xu, Xiaodan Kou, Yuan Cheng

    pp. 321–327 · DOI: 10.4103/pm.pm_345_21 · Published 7 July 2022

    Background: Astilbin is a flavonoid phytoconstituent extracted from Chinese herb Rhizoma Smilacis Glabrae, a common Chinese food ingredient.Objectives: The present study used astilbin as a model drug to develop food‑base…

12. Article

    Antitumor and Immunomodulation of Total Flavonoids from the Green Peep of Juglans regia L. in Mouse Forestomach Carcinoma Gastric Cancer‑Bearing Mice

    Baozhong Wei, Hongxia Zhu, Kai Wang, Shuangming Liu, Yihui Dai, Danhong Liu, Fengguo Xia, Hua Sun

    pp. 328–333 · DOI: 10.4103/pm.pm_54_21 · Published 7 July 2022

    Background: Gastric cancer is a malignant tumor of the digestive tract. It is the fifth most common cancer and the third leading cause of cancer death across the world. In this study, we investigated the antitumor and im…

13. Article

    Oridonin Regulates NF‑κB Signaling Pathway in Gestational Diabetes Suppression of SPARC and G6pase in C57BL/6J Mice

    Jinjin Qin, Bei Wang, Rui Li, Fang Wang, Yan An, Chenyuan Cao

    pp. 334–340 · DOI: 10.4103/pm.pm_146_21 · Published 7 July 2022

    Background: In recent years, the morbidity of gestational diabetes (GD) has increased by around 5%–10%, and it now affects around 8%–21% of all births, with around 3%–5% of these women suffering from long‑term diabetes a…

14. Article

    Potential Role of Tribulus terrestris Fruit Extract in Inhibition of Advanced Glycation End Products

    Dinesh Kumar, Nidhi Shah, Khalid M. Al‑Anazi, Mohammad Abul Farah, M. Ajmal Ali, Joongku Lee, Ahmad Ali

    pp. 341–347 · DOI: 10.4103/pm.pm_589_21 · Published 7 July 2022

    Background: Glycation refers to the interaction between sugars and proteins leading to the production of harmful advanced glycation end‑products (AGEs). Many different diseases such as neurodegenerative, cardiovascular, …

15. Article

    Goniothalamin Alleviates Inflammation and Arthritic Markers in Adjuvant‑Induced Arthritis in Rats

    Dong Yang, Guangfeng Niu, Jie Guo

    pp. 348–352 · DOI: 10.4103/pm.pm_257_21 · Published 7 July 2022

    Background: Goniothalamin (GTN) is a well‑known styryl lactone that possesses anti‑inflammatory and anticancer properties. In this study, we evaluated the potential of GTN on experimental arthritis based on the complete …

16. Article

    Growth stage‑specific Accumulation of Cardiac Glycosides in Two Variants of Calotropis gigantea (L.) W.T. Aiton

    Pankaj Singh, Yatendra Singh, Sanjeev Kanojiya, Vineeta Tripathi, Dipak Kumar Mishra

    pp. 353–359 · DOI: 10.4103/pm.pm_525_21 · Published 7 July 2022

    Background: Calotropis gigantea (L.) W.T. Aiton, belonging to the family Apocynaceae, is a source of many bioactive cardiac glycosides. Accumulation of secondary metabolites in plants depends upon various external and in…

17. Article

    Evaluation of Apoptotic and Cytotoxic Effect of Robinin in TPC‑1 and SW1736 Human Thyroid Cancer Cells

    Yawei Shen, Periyannan Velu, Xin Huang, Taoping Dang

    pp. 360–365 · DOI: 10.4103/pm.pm_270_21 · Published 7 July 2022

    Background: During the past few years, thyroid cancer (TC) has increased in terms of rate of morbidity and mortality. Plant flavonoids have shown positive effect in regulating thyroid tumorigenesis via inhibition of apop…

18. Article

    Molecular Effect of Betanin on the Molecular Expression Pattern of Cell Proliferative and Inflammatory Signalling Pathways in DMBA‑Induced Oral Carcinogenesis in Hamsters

    Yingying Fan, Ge Ma, Qingyan Guo, Jian Wang, Periyannan Velu

    pp. 366–372 · DOI: 10.4103/pm.pm_281_21 · Published 7 July 2022

    Background: Cancer development is a sequential process as a result of various cellular adaptation events. Oral cancer (squamous cell carcinoma) is the most predominant variety of head and neck cancer. Betanin (BTN) is is…

19. Article

    β‑Caryophyllene Reduced Oxidative Stress and Expression of Apoptotic Markers in Streptozotocin‑Induced Diabetic Rats

    Binghong Hua, Yin Xiao, Fuling Li

    pp. 373–377 · DOI: 10.4103/pm.pm_331_21 · Published 7 July 2022

    Purpose: In this study, we aimed to investigate the effects of β‑caryophyllene against oxidative stress‑induced apoptosis in the animal model of diabetes. Materials and Methods: Experimental diabetes was induced in the r…

20. Article

    Effect of Lycium Barbarum Polysaccharide Combined with Cisplatin on the Proliferation of Human Lung Cancer Cells

    Yunfan Liu, Yuemei Du, Liping Gao

    pp. 378–385 · DOI: 10.4103/pm.pm_354_21 · Published 7 July 2022

    Background: Lycium barbarum polysaccharide (LBP) is a water‑soluble polysaccharide extracted from Lycium barbarum. LBP exhibits potential pharmacological activity, including anti‑cancer activities. However, so far, the e…

21. Article

    Natural Anti‑Hepatitis B Virus Flavones Isolated from schimperi Vatke Growing in Saudi Arabia: Cell Culture and Molecular Docking Study

    Sarfaraz Ahmed, Mohammad K. Parvez, Komal Zia, Mohammad Nur‑e‑Alam, Zaheer Ul‑Haq, Mohammed S. Al‑Dosari

    pp. 386–392 · DOI: 10.4103/pm.pm_600_21 · Published 7 July 2022

    Background: Stachys schimperi Vatke has been previously reported for its analgesic, antipyretic, antioxidant, antimicrobial and cardioprotective properties. Objectives: Phytochemical analysis and assessment of anti‑hepat…

22. Article

    Ruanmailing Oral Liquid Inhibits Atherosclerosis in ApoE−/− Mice via Regulation of TGF‑β1/SMAD4 Signaling Pathway

    Tianmin Wu, Xuanbin Huang, Wenjuan Xue, Liufang Fan, Wenyan Xie, Youzhen Huang, Jinshui Chen

    pp. 393–399 · DOI: 10.4103/pm.pm_410_21 · Published 7 July 2022

    Background: In this study, we aimed to investigate the effect of Ruanmailing oral liquid on atherosclerosis and transforming growth factor (TGF)‑β1/ SMAD4 signaling pathway in apolipoprotein E‑knockout (ApoE−/−) mice ind…

23. Article

    Celastrus paniculatus Seed Oil Ameliorates Oxidative Stress in Lipopolysaccharide‑Induced Respiratory Inflammation in Mice

    William R. Surin, Eveline J. Sharon, Archana Kullu, Santhosh Kacham, Sandya S

    pp. 400–405 · DOI: 10.4103/pm.pm_575_21 · Published 7 July 2022

    Background: Celastrus paniculatus have been reported to possess various medicinal properties. However, very little is known about itseffect on respiratory inflammation. Objectives: We evaluated Celastrus paniculatus seed…

24. Article

    Exploring the Potential Quality Marker of Traditional Tibetan Medicine Erigeron multiradiatus Based on Ultra‑High Performance Liquid Chromatography‑Quadrupole Time‑of‑Flight Mass Spectrometry Analysis, Network Pharmacology, and Experimental Verification

    Amu Hamamozhi, Jing Li, Xuyan Su, WenfuCai WenfuCai, Riza Zhao, Zhifeng Zhang

    pp. 406–417 · DOI: 10.4103/pm.pm_344_21 · Published 7 July 2022

    Background: Erigeron multiradiatus (EM), a well‑known traditional Tibetan medicine, has been used for hundreds of years to treat various chronic metabolic diseases. However, previous studies on EM have primarily focused …

25. Article

    Structural Characterization and Emulsifying Properties of a Water‑Soluble Buchanania lanzan Gum Polysaccharide

    Saptarshi Samajdar, K. Jayaram Kumar

    pp. 418–426 · DOI: 10.4103/pm.pm_96_22 · Published 7 July 2022

    Background: Buchanania lanzan gum, better known as chironji gum, has been traditionally used as a binder in food preparations.Water‑soluble polysaccharides have good emulsifying properties, but the polysaccharide structu…

26. Article

    Combination of Platelet Bio‑Specific Extraction and High‑performance Liquid Chromatography with Diode‑Array Detection/Liquid Chromatography‑Mass Spectrometry Method for Analyzing Platelet‑targeted Compounds in Rhizoma Chuanxiong

    Qian Zhang, Yuxiu Yang, Yao Xiao, Fenqing Wang, Yuanjia Hu, Zhining Xia, Fengqing Yang

    pp. 427–434 · DOI: 10.4103/pm.pm_390_16 · Published 7 July 2022

    Context: Platelet is an important pharmacological target as it participates in complex processes of coagulation and hemostasis. Excessive platelet aggregation is responsible for the formation of pathogenic thrombi in pat…

27. Article

    Protective Effect of Fermented Cudrania tricuspidata Fruit Extracts on Acute Rat Reflux Esophagitis

    Li Nan, Hyeon‑Hwa Nam, Byung‑Kil Choo

    pp. 435–442 · DOI: 10.4103/pm.pm_481_21 · Published 7 July 2022

    Background: Reflux esophagitis (RE) is a type of gastroesophageal reflux disease (GERD) that severely reduces the quality of life. The Cudrania tricuspidata (C. tricuspidata) fruit is commonly used in food and has medici…

28. Article

    Combined Network Pharmacology and Cell Experiments to Explore the Anti‑Inflammatory Mechanisms of Matrine

    Lichao Wu, Fangfang Tao, Tengfei Sun, Junhui Zhao, Junfeng Li, Wenhong Liu

    pp. 443–449 · DOI: 10.4103/pm.pm_431_21 · Published 7 July 2022

    Background: Matrine is an alkaloid compound isolated from the root of Sophorae Flavescentis Radix. Despite being a potent anti‑inflammatory agent, the underlying mechanisms of these anti‑inflammatory properties have not …

29. Article

    Improvement Effect of Evodiae Fructus Water Extract against DSS‑induced Ulcerative Colitis

    Min Ju Kim, Jin A. Lee, Mi‑Rae Shin, Ji Hye Lee, Hae‑Jin Park, Sanghyun Lee, Seong‑Soo Roh

    pp. 450–457 · DOI: 10.4103/pm.pm_465_21 · Published 7 July 2022

    Background: Evodiae fructus is a natural plant that is used as a medicinal material in many Asian countries such as Korea and China. However, little is known about its effect on ulcerative colitis. Objectives: Thus, the …

30. Article

    Quercetin of Potentilla bifurca 3‑Glycosylation Substitution Impact the Inhibitory Activity on α‑glucosidase

    Xuanzhao Qu, Jinping Li, Peiying Yan, Guiyao Wang, Wei Liu, Yang Zeng, Likuan Liu

    pp. 458–462 · DOI: 10.4103/pm.pm_522_21 · Published 7 July 2022

    Background: Inhibition of glycosidase activity is an effective diabetes therapy and prevention strategy. In this study, we aimed to explore the effects of quercetin and its derivatives extracted from Potentilla bifurca o…