Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Goniothalamin Alleviates Inflammation and Arthritic Markers in Adjuvant‑Induced Arthritis in Rats

    Dong Yang1, Guangfeng Niu2,3, Jie Guo4★★ Corresponding author

    1. 1Department of Joint Surgery, The Third Hospital of Jinan, Jinan, China.
    2. 2Department of Orthopaedics, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
    3. 3Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
    4. 4Department of Spine Joint Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

    CORRESPONDENCE

    Jie Guo

    Department of Spine Joint Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

    guoguo20180629@sina.com

    Received: 10-06-2021; Revised: 03-02-2022; Accepted: 11-03-2022.

    Volume 18, Issue 78 · pp. 348–352 · PUBLISHED 7 July 2022 · DOI: 10.4103/pm.pm_257_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Goniothalamin (GTN) is a well‑known styryl lactone that possesses anti‑inflammatory and anticancer properties. In this study, we evaluated the potential of GTN on experimental arthritis based on the complete Freund’s adjuvant (CFA)‑induced arthritis model in rats and the effect was compared with standard drug. Materials and Methods: The animals were divided into six groups: normal, CFA, CFA + indomethacin (10 mg/kg bw), CFA + GTN (50 mg/kg bw), CFA + GTN (100 mg/kg bw), and GTN (100 mg/kg bw) alone. The antiarthritic activity of GTN was measured by paw thickness, arthritic score, body weight, organ weight, biochemical markers, inflammatory mediators, and histopathologic analysis of ankle joints. Results: GTN significantly reduced the paw thickness, arthritic score, body weight changes, and organ weight. It reduced the levels of C‑reactive protein, alkaline phosphatase, rheumatoid factor, and proinflammatory cytokines in a dose‑dependent manner. It also minimized the histopathologic changes in ankle joints induced by CFA in a dose‑dependent manner. Conclusion: These results demonstrate that GTN is effective against inflammation and is an alternative agent for the management of arthritis.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Yang, D., Niu, G., & Guo, J. (2022). Goniothalamin Alleviates Inflammation and Arthritic Markers in Adjuvant‑Induced Arthritis in Rats. Pharmacognosy Magazine, 18(78), 348–352. https://doi.org/10.4103/pm.pm_257_21