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    Article

    Exploring the Beneficial Role of Ononin in Preventing Ovariectomy‑Induced Osteoporosis In Rats Via Osx And Runx2 Pathway

    Tonghao Wang¶2,3, Lijun Tian¶2,4, Lilong Du5, Guowang Li6, Yongjin Li6, BaoShan Xu2,5★★ Corresponding author

    1. 1Clinical College of Orthopedics, Tianjin Medical University, Tianjin.
    2. 2Department of Orthopedic, The Third Central Hospital of Tianjin, Tianjin.
    3. 3Department of Orthopedic, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology Baotou, Inner Mongolia.
    4. 4Department of Minimally Invasive Spine Surgery, Tianjin Hospital, Jiefang South Road 406, Hexi District, Tianjin.
    5. 5Graduate School, Tianjin Medical University, Tianjin, China ¶Equal contribution.

    CORRESPONDENCE

    BaoShan Xu

    Department of Orthopedic, The Third Central Hospital of Tianjin, Tianjin.

    baoshanxu99@tmu.edu.cn

    Received: 25-06-2021; Revised: 18-06-2022; Accepted: 01-08-2022.

    Volume 18, Issue 80 · pp. 1055–1065 · PUBLISHED 23 November 2022 · DOI: 10.4103/pm.pm_282_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: In this study, we aimed to evaluate the efficacy of ononin against ovariectomy(OVX)‑induced osteoporosis in female rats. Materials and Methods: Ovaries were removed surgically to develop the animal model of OVX. Animals (n = 4) were grouped into control, OVX induced, OVX rats treated with ononin (10 mg/kg body weight), and OVX rats treated with 20 mg/kg body weight of ononin. Results: OVX rats treated with ononin showed improved body weight, uterus index, inflammatory and bone markers, serum lipid profile, and calcium level. Ononin downregulated the expression of estrogen (E2), acid phosphatase, and bone gamma‑carboxyglutamate (Gla) protein in OVX rats. It also restored trabecular area and thickness, which was evidenced by histomorphometrical and histopathological examination. Ononin attenuated the expression of alkaline phosphatase, osterix, and Runx2 in OVX rats. Conclusion: In summary, our results suggest that ononin could be used as an ideal therapeutic agent to prevent and treat bone‑associated disorders.

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      Wang¶, T., Tian¶, L., Du, L., Li, G., Li, Y., & Xu, B. (2022). Exploring the Beneficial Role of Ononin in Preventing Ovariectomy‑Induced Osteoporosis In Rats Via Osx And Runx2 Pathway. Pharmacognosy Magazine, 18(80), 1055–1065. https://doi.org/10.4103/pm.pm_282_21