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    Article

    Evaluation of Hair Growth Properties of Glycyrrhizic Acid

    Bing Zhang2, Wenyun Zhang2,3, Jianfang Luo2,3, Jian He2,3, Baoshan Rong2,3, Xiaomin Zheng2,3, Siyang Zhu3, Xian Xu3, Yong Ai2,3, Lanyue Zhang4,5★, Tinggang He3★★ Corresponding author

    1. 1Guangdong He Ji Biotech Co., Ltd., Guangzhou, China.
    2. 2Hua An Tang Biotech Group Co., Ltd., Guangzhou, China.
    3. 3School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.
    4. 4Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou, Guangzhou, P.R, China.

    CORRESPONDENCE

    Lanyue Zhang

    Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou, Guangzhou, P.R, China.

    zhanglanyue@gdut.edu.cn

    Received: 30-11-2021; Revised: 29-03-2022; Accepted: 01-08-2022.

    Volume 18, Issue 80 · pp. 1111–1117 · PUBLISHED 23 November 2022 · DOI: 10.4103/pm.pm_552_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The aim of this study was to investigate the potential hair blackening effect and mechanisms of glycyrrhetic acid (GA) extracted from Glycyrrhiza uralensis. Materials and Methods: Different concentrations of GA solution (1.0 wt%, 10.0 wt%, and 20.0 wt%) were coated onto the skin surface of fur model mice induced by H2O2 for two weeks. After that, the number and depth of follicles and cortex thickness were observed in the skin tissue stained by hematoxylin and eosin (H&E). The relative mRNA levels of β‑catenin, vascular endothelial growth factor (VEGF), and tyrosinase in skin tissue were analyzed using quantitative real‑time polymerase chain reaction. The protein levels of β‑catenin, VEGF, and tyrosinase were also evaluated by western blotting and immunohistochemistry. Results: There was a marked increase in the number of hair follicles and the blackening effect upon exposure to 10.0 wt% and 20.0 wt% GA. Moreover, the β‑catenin, VEGF, and tyrosinase expression levels in the skin tissue varied significantly compared to those in the model group. Conclusion: GA showed positive effects on hair growth factor expression levels in mice, which meant that GA could promote hair blackening.

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      Zhang, B., Zhang, W., Luo, J., He, J., Rong, B., Zheng, X., Zhu, S., Xu, X., Ai, Y., Zhang, L., & He, T. (2022). Evaluation of Hair Growth Properties of Glycyrrhizic Acid. Pharmacognosy Magazine, 18(80), 1111–1117. https://doi.org/10.4103/pm.pm_552_21