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    Article

    Citri Unshius Pericarpium Improves Dexamethasone‑Induced Muscle Atrophy in Mice

    Seong‑Wook Seo1, Sang‑Cheol Im2, Kyoung Kim2★★ Corresponding author

    1. 1Department of Rehabilitation Sciences, Graduate School, Daegu University, Gyeongsangbuk‑do.
    2. 2Department of Physical Therapy, College of Rehabilitation Sciences, Daegu University, Gyeongsangbuk‑do, Republic of Korea.

    CORRESPONDENCE

    Kyoung Kim

    Department of Physical Therapy, College of Rehabilitation Sciences, Daegu University, Gyeongsangbuk‑do, Republic of Korea.

    kykim257@hanmail.net

    Received: 28-01-2022; Revised: 19-04-2022; Accepted: 12-07-2022.

    Volume 18, Issue 80 · pp. 851–858 · PUBLISHED 23 November 2022 · DOI: 10.4103/pm.pm_46_22

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: Accordingly, the current study was performed to evaluate the effects and the underlying mechanisms of CP on dexamethasone (DEX)‑provoked muscle atrophy in C57BL/6 mice. Materials and Methods: The 8‑week‑old mice were treated once a day (DEX 20 mg/kg body weight, i.p.), and CP was administrated orally for 10 days. Then, we measured the body weight, swimming time, and muscle weight, and histological evaluation and western blot were performed. Results: CP improved muscle function decline by bettering the swimming time and muscle weight to some extent. Moreover, histological muscle damage induced by DEX was enhanced through CP treatment. CP treatment induced the reduction of ROS‑related factors. CP showed a decrease in the protein expressions such as myostatin, Atrogin‑1, and MuRF1 via the down‑regulation of the phosphorylation of AMPK. Besides, in the CP group, muscle protein synthesis was increased by the PI3K/Akt/mTOR signaling pathway. Conclusion: Taken together, CP could be highly commercialized as a commercial material for functional food for the prevention and improvement of muscle loss, which is induced by muscle atrophy.

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      Seo, S., Im, S., & Kim, K. (2022). Citri Unshius Pericarpium Improves Dexamethasone‑Induced Muscle Atrophy in Mice. Pharmacognosy Magazine, 18(80), 851–858. https://doi.org/10.4103/pm.pm_46_22