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    Article

    Anticancer Potential of Vernodalin on Diethylnitrosamine Induces Liver Cancer by Inhibition of Cell Proliferation

    Yifei Guo2, Xuan Li Li2, Yao Qu2, Lei Yan3,4, Shengping Lei3,4, Chenguang Yang5★★ Corresponding author

    1. 1The First Clinical Medical College, Shaanxi University of Chinese Medicine, 1 Century Avenue, Qindu District, Xianyang City, Shaanxi Province, China.
    2. 2Clinical Experimental Centre, Xi’an International Medical Center Hospital, Shaanxi University of Chinese Medicine, No. 777 Xitai Road, High‑Tech Zone, Xi’an, Shaanxi Province, China.
    3. 3Xi’an Engineering Technology Research Center for Cardiovascular Active Peptide, No. 777 Xitai Road, High‑Tech Zone, Xi’an, Shaanxi Province, China.
    4. 4Department of Oncology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xihuamen No. 2, Lianhu District, Xi’an City, Shaanxi Province, China.

    CORRESPONDENCE

    Chenguang Yang

    tcm_oncology@163.com

    Received: 25-12-2021; Revised: 24-03-2022; Accepted: 01-08-2022.

    Volume 18, Issue 80 · pp. 994–999 · PUBLISHED 23 November 2022 · DOI: 10.4103/pm.pm_599_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: To investigate the chemopreventive and apoptotic effect of vernodalin in diethylnitrosamine (DEN) induced HCC. Materials and Methods: Rats were distributed into four sets of experimental animals every six rats: control group, DEN alone, DEN + vernodalin, (10 mg/kg bw), and vernodalin (10 mg/kg bw) alone. The analysis was conducted to measure the liver and body weight. The assay was designed to analyze hepatic toxic markers, antioxidants, lipid peroxides, and inflammatory cytokines, in addition, histopathology and western blot analysis were also conducted. Results: DEN with vernodalin diminished weight of the body and antioxidant level whereas raised the liver weight, toxic marker concentration, oxidative stress and cytokines. Vernodalin also prevents oxidative stress, lipid peroxides level, toxic markers, pro‑inflammatory, and cytokines. Vernodalin suppressed the P13K/AKT signaling that enhances apoptosis and maintains the morphology of cells. Conclusion: The results indicate that vernodalin exerts a promising chemopreventive and apoptotic natural agent for DEN‑induced HCC in rats.

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      Guo, Y., Li, X. L., Qu, Y., Yan, L., Lei, S., & Yang, C. (2022). Anticancer Potential of Vernodalin on Diethylnitrosamine Induces Liver Cancer by Inhibition of Cell Proliferation. Pharmacognosy Magazine, 18(80), 994–999. https://doi.org/10.4103/pm.pm_599_21