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    Voacangine Mitigates Human Nasopharyngeal Carcinoma Cells HK-1 Proliferation and Triggers Apoptosis through the Suppression of NF-κB Facilitated PI3K/AKT/mTOR Pathway

    Aihui Hou1, Huimin Zhen2, Xiaofeng Qiao3, Herong Dang2, Yuanfeng Shen4★★ Corresponding author

    1. 1Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Shandong, China
    2. 2Shanxi University of Chinese Medicine, Taiyuan, Shanxi, China
    3. 3Department of Otorhinolaryngology, Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China
    4. 4Department of Otolaryngology, Huzhou Traditional Chinese Medicine Hospital, Huzhou, Zhejiang, China

    CORRESPONDENCE

    Yuanfeng Shen

    Department of Otolaryngology, Huzhou Traditional Chinese Medicine Hospital Huzhou, Zhejiang 313000, China.

    shenyuanfeng0572@sina.com

    Received: 03-01-2023; Accepted: 20-06-2023.

    Volume 19, Issue 4 · pp. 1012–1020 · PUBLISHED 2023 · DOI: 10.1177/09731296231197274

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The nasopharyngeal epithelium, which is frequently found in Southeast Asia and Southern China, gives rise to nasopharyngeal carcinoma (NPC). Despite improvements in diagnostic tools and remedial modalities, the prognosis of NPC remains meager. Thus, innovative and effective anti-cancer agents are desirable. Voacangine (VCG) is a recognized alkaloid sequestered from the plant Voacanga foetida. Hence, the current research assessed the anti-proliferative and apoptotic action of VCG on HK-1 human NPC cells and its underlying molecular actions. The results exposed that VCG (20 and 25 μ/ml) avert the HK-1 cells proliferation, which stimulates apoptosis by the amelioration of Bcl-2-associated X protein (Bax) and caspases, while it lessens cyclin-D1, B-cell lymphoma 2 (Bcl-2), c-Myc, survivin in a dose-dependent way. Furthermore, VCG alleviates inflammation, cell proliferation, and augmented cell death through the attenuation of Nuclear factor kappa B (NF-κB) facilitated Phosphoinositide 3-kinase/Protein kinase B/Mammalian target of rapamycin (PI3K/AKT/mTOR) signaling. This creates a Bax/Bcl-2 proportion imbalance, which triggers caspases cascade, Cyt-c, and induces apoptosis. Our findings deliver novel perceptions into exploring VCG as a beneficial bioactive alkaloid for the handling of NPC.

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      Hou, A., Zhen, H., Qiao, X., Dang, H., & Shen, Y. (2023). Voacangine Mitigates Human Nasopharyngeal Carcinoma Cells HK-1 Proliferation and Triggers Apoptosis through the Suppression of NF-κB Facilitated PI3K/AKT/mTOR Pathway. Pharmacognosy Magazine, 19(4), 1012–1020. https://doi.org/10.1177/09731296231197274