Volume 19, Issue 4

2023 · pp. 799–1036 · 22 articles

Volume: 19
Issue: 4
Published: 2023
Pages: 799–1036
Articles: 22
Sections: 2
ISSN: ISSN: Print - 0973-1296, Online - 0976-4062
Journal: Pharmacogn. Mag.

Original Article Review Article

In this issue

Original Article

Article
Effect of Ligustrazine on Lipopolysaccharide-induced Inflammatory Response of Vascular Endothelial Cells and its Possible Mechanism
Xia Meng Zhang, Zehong Ma, Chengjian Mao, Jihong Zhang, Zhongdanni Ma
pp. 994–1002 · DOI: 10.1177/09731296231197077 · Published 2023
Background: Endothelial cell (EC) inflammation plays a crucial role in the development of several cardiovascular disorders (CD), including atherosclerosis and sepsis. Ligustrazine (Lig), a bioactive constituent derived f…
Article
In vitro Neuroprotective Activity of Vigna radiata L. and Vigna pilosa L. on Amyloid Beta-induced Cytotoxicity
N. V. Prasanth, P. Pandian, T. Balasubramanian
pp. 1003–1011 · DOI: 10.1177/09731296231200509 · Published 2023
Background: Alzheimer’s disease (AD) is considered to be the most common form of dementia. The drugs that are available for the treatment of AD provide only partial improvement of the condition. In recent years, natural …
Article
Voacangine Mitigates Human Nasopharyngeal Carcinoma Cells HK-1 Proliferation and Triggers Apoptosis through the Suppression of NF-κB Facilitated PI3K/AKT/mTOR Pathway
Aihui Hou, Huimin Zhen, Xiaofeng Qiao, Herong Dang, Yuanfeng Shen
pp. 1012–1020 · DOI: 10.1177/09731296231197274 · Published 2023
The nasopharyngeal epithelium, which is frequently found in Southeast Asia and Southern China, gives rise to nasopharyngeal carcinoma (NPC). Despite improvements in diagnostic tools and remedial modalities, the prognosis…
Article
Scutellarin Protects Myocardial Ischemia-Reperfusion Injury ERK1/2-CREB Regulated Mitophagy
Wei-Wei Wang, Xiao-Lei Liu, Yu Ding, Ya-Di Chen, Dan Ma, Rui Bu, Tian-Hao Bao
pp. 1021–1036 · DOI: 10.1177/09731296231199860 · Published 2023
Objectives: Scutellarin, which is obtained from Erigeron breviscapus Hand-Mazz (EBHM), is a flavonoid that has demonstrated the ability to safeguard neural stem cells from hypoxia-induced damage and prevent cell apoptosi…
Article
The Protective Effect of Ginkgolide K on Astrocytes Exposed to Myelin Debris in vitro and Demyelination in vivo
Xiao-Hui Li, Ke-Xin Liu, Zhi-Bin Ding, Qing Wang, Li-Juan Song, Jie-Zhong Yu, Dong Ma, Bao-Guo Xiao, Cun-Gen Ma
pp. 811–821 · DOI: 10.1177/09731296231171454 · Published 2023
Background: Ginkgolide K (GK) has a protective effect on neurons and myelin sheath, and the function of astrocytes in phagocytizing myelin debris has attracted extensive attention in remyelination. Objectives: This study…
Article
Investigation of Neuroprotective Effects of Sulforaphane and Allyl Isothiocyanate in an in vitro Alzheimer’s Disease Model
Fatma Hacet, Eda Becer, Hafize Seda Vatansever, Sevinç Yücecan
pp. 822–830 · DOI: 10.1177/09731296231187443 · Published 2023
Background: This study aimed to establish an in vitro model of Alzheimer’s Disease (AD) to investigate the neuroprotective activities of allyl isothiocyanate (AITC) and sulforaphane (SFN). Materials and Methods: Human ne…
Article
Development and Application of qPCR Assay for Species-specific Identification of Two Animal-derived Tonics: Vinegarquenched Testudinis Carapax et Plastrum and Vinegar-quenched Trionycis Carapax
Chao Xu, Xiang Chen, Jing Han, Yufei Chen, Chongyu Ge, Liwei Wang, Rong Yang, Yuping Shen, Huan Yang
pp. 831–840 · DOI: 10.1177/09731296231188779 · Published 2023
Background: Vinegar-quenched Testudinis Carapax et Plastrum (TCP) and vinegar-quenched Trionycis Carapax (TC) are made from the shells of Chinemys reevesii and Trionyx sinensis. However, some cheap substitutes from non-m…
Article
Fermented Cordyceps Powder Attenuates Inflammation and Pulmonary Arterioles Remodeling by Inhibiting p38 MAPK/NF-κB Signaling Pathway in Hypoxic Pulmonary Hypertension Rats
Jia Li, Tingting Chen, Zhanting Yang, Shanshan Su, Yuhua Wang, Zhanqiang Li, Dianxiang Lu
pp. 841–852 · DOI: 10.1177/09731296231194402 · Published 2023
Background: Pulmonary hypertension (PH) is a pulmonary vascular disease caused by a variety of causes and has a poor prognosis. Hypoxic pulmonary hypertension (HPH) is one of the types of PH. Cordyceps sinensis could tre…
Article
Corilagin Induces ROS-mediated Apoptosis and Triggers Cell-Cycle Arrest at G0/G1 Stage in Osteosarcoma Cells
Jichao Liu, Dong Yang, Jianyu Liu
pp. 853–861 · DOI: 10.1177/09731296231184539 · Published 2023
Background: Osteosarcoma (OS) is an extremely aggressive primary bone cancer (BC) malignancy. A variety of malignancies can develop in the bones, including BC. Primary BCs are tumors that start in the bone. Bones can als…
Article
Evaluation of Preclinical in vitro Cytotoxicity, Genotoxicity, and Cardiac-Toxicity Screenings of Hydrogenated Cannabidiol
Tesfay T. Tesfatsion, Giovanni A. Ramirez, Maite L. Docampo-Palacios, Arianna C. Collins, Kyle P. Ray, Westley Cruces
pp. 862–873 · DOI: 10.1177/09731296231195941 · Published 2023
Introduction: Cannabidiol (CBD) is one of many naturally biosynthesized compounds produced by Cannabis sativa. There is limited information available in the literature on hydrogenated CBD (tetrahydro cannabidiol or H4CBD…
Article
Induction of Apoptosis by Cynaropicrin in Human Colon Cancer Cell Line HCT-116 through the Mitochondria-mediated Apoptotic Pathway
Lei Wang, Xiaoqin Bie, Suresh Mickymaray, Abdulaziz S. Alothaim, Yan Pei, Huaping Gong
pp. 874–884 · DOI: 10.1177/09731296231183833 · Published 2023
Background: Colon cancer continues to be the third most commonly occurring cancer around the globe with both lifestyle-related risk factors and genetic dispositions. Owing to the increased incidence of the disease, there…
Article
Mechanisms of Herba Epimedii in Lung Cancer Treatment: A Combination of Molecular Docking and Network Pharmacology Analyses
Jinhua Zhang
pp. 885–897 · DOI: 10.1177/09731296231189095 · Published 2023
Introduction: Lung cancer (LC) ranks among the most prevalent malignant neoplasms globally. As a Traditional Chinese medicine (TCM), Herba Epimedii has been commonly used for treating LC. However, the specific mechanism …
Article
Apigenin-induced Apoptosis is Reduced via Endoplasmic Reticulum Stress and ATF6/PERK Signaling in Human Gastric Cancer Cells
Cuizhu Zhuo, Xiaolin Wang, Yun Li, Yongmei Tang, Manman Wang, Liying Hou
pp. 898–905 · DOI: 10.1177/09731296231188792 · Published 2023
Background: Apigenin effectively inhibits the growth of human gastric carcinoma SGC-7901 cells and induces apoptosis as well. This study investigated the effects of ATF6 and PERK signaling pathways in unfolded protein re…
Article
Schefflera arboricola Tablets Relieve Diabetic Neuropathic Pain: Involvement of Oxidative Stress and Inflammation
Shaomei Lin, Yunzhu Shen, Xiaowei Huang, Shifeng Lin, Xiaoning Shi
pp. 906–916 · DOI: 10.1177/09731296231193801 · Published 2023
Background: Diabetic neuropathic pain (DNP) is a serious chronic complication of diabetes mellitus. Oxidative stress and inflammation are considered the central mechanisms of its pathogenesis. Schefflera arboricola (SA) …
Article
Comparative Chemical Profiling of a Polyherbal Formulation with Respect to its Ingredient Plants Using Spectrophotometric and High-performance Thin-layer Chromatographic Techniques
Cheruthazhakkat Sulaiman, Thankayathil Shafna, Geetha Raguthaman Advaya, Poovathusseri Raghava Varier Ramesh, Kamalakshan Pillai Mahesh, Mooriath Praveen, Erayur Mana Anandan, Indira Balachandran
pp. 917–925 · DOI: 10.1177/09731296231200365 · Published 2023
Background: Guggulutiktam Kashayam (GTK) is a water decoction used in Ayurveda for the treatment of various diseases like skin diseases, ulcers, anemia, thyroid problems, stress, liver disease, and leucorrhoea. It is a p…
Article
Ponicidin Induces Apoptosis and Inhibits Tumor Growth in C666-1 Nasopharyngeal Cancer Cells
Yuanfeng Shen, Lu Zhang, Aihui Hou, Kaviya Suresh, Anbarasan Balu, Zhe Gong
pp. 926–936 · DOI: 10.1177/09731296231183277 · Published 2023
Background: Nasopharyngeal carcinoma (NPC), predominant in Southern China and Southeast Asia, is a malignant tumor that arises from the epithelial lining of the nasopharynx. Current NPC treatments result in unfavorable s…
Article
Optimization of the Integrated Processing Technology of Primary Processing for Asparagi Radix by HPLC-CAD Combined with the Box-Behnken Design
Ju Zhang, Bing Wang, Guanglin Zhu, Guo Feng, Wei Li, Hongmei Su, Wenjing Wang, Xie-an Yu, Xueli Song, Zhengyan He
pp. 937–945 · DOI: 10.1177/09731296231191375 · Published 2023
Background: Asparagi Radix (AR) is one of the widely used Traditional Chinese Medicines (TCMs) for clinical applications, owning the effects of clearing the lungs and promoting body fluid, nourishing yin, and moistening …
Article
Catalpol Ameliorates Myocardial I/R Injury Through PI3k/Akt/P53 Signaling-mediated Anti-autophagy and Anti-apoptosis
Lingai Hu, Yukun Sun, Hongsheng Zhang, Yong Cao, Jinguo Zhang
pp. 946–953 · DOI: 10.1177/09731296231189557 · Published 2023
Background: Myocardial infarction (MI) is a leading cardiovascular disease worldwide, with high mortality. Purpose: The study aimed to observe the mechanism of catalpol inhibiting apoptosis and autophagy in H9c2 cells af…
Article
Network Pharmacology-based Analysis of the Effects of Huangqi Guizhi Wuwu Decoction on Ischemic Stroke*
Xiaoyang Gong, Jiaqi Zhou, Haonan Xia, Chong You, Yong Liu
pp. 954–966 · DOI: 10.1177/09731296231189106 · Published 2023
Background: The purpose of this study was to investigate the molecular mechanisms and material basis of Huangqi Guizhi Wuwu Decoction (HGWD) in treating clinical Ischemic stroke (IS) using network pharmacology and molecu…
Article
Bioinformatics, Molecular Docking Simulation and in vitro Experiments Reveal the Bioactive Compounds and Mechanism of Coptis chinensis Franch. Against Colorectal Adenocarcinoma
Xin Liu, Xu-ying Huang, Zhong Liu, Li Liu, Han Tu
pp. 967–980 · DOI: 10.1177/09731296231189553 · Published 2023
Background: Coptis chinensis Franch. (CCF) is a Traditional Chinese medicine known for its good anti-cancer effects. However, the bioactive compounds and mechanisms underlying its anti-colorectal adenocarcinoma (COAD) re…
Article
Network Pharmacology-based Analysis to Investigate Bioactive from the Root of Astragalus membranaceus against Immunomodulatory Protein and their Role in Autoimmune Thyroiditis (AIT)
Yi Wen, Changda Li, Yifan Zeng, Chanyuan Zhou, Qiang Zhang, Tianshu Gao
pp. 981–993 · DOI: 10.1177/09731296231189561 · Published 2023
Background: The thyroid is the prime organ of infection during the onset of autoimmune disease. The disease is known as Autoimmune thyroiditis (AIT). In recent times, AIT has been alarming worldwide, with growing attenti…

Review Article

Review
A Comprehensive Review on Possible Synergistic Therapeutic Effects and Comparison Between Phytochemical and Nutritional Profile of Medicago sativa and Panax ginseng
Sachin Kumar, Ashok Kumar, Suhasini Nayal, Aman Shukla, Shashank Kailkhura
pp. 799–810 · DOI: 10.1177/09731296231197306 · Published 2023
Medicago sativa is the “Father of all herbs” or “King of Herbs,” and Panax ginseng is the “‘Man root” or “Herb for all healings.” Individually, both have copious numbers of phytochemicals and nutrients like flavonoids, s…