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    Pharmacognosy MagazineNOW IN
    Article

    Effects of Mineral Chinese Medicine Chloriti Lapis on Gut Microbiota of Small Intestine in PTZ-kindling Epileptic Rats

    Peng Yuan1,2,3, Fengtao Li4, Xilong Qian1,2,3, Yulu Ma1,2,3, Xiuxiu Wang5, Qian Zhao6, Xingyu Zhu7, Baofei Yan4, Liu Zhou1,2,3, Wei Yang1,2,3, Yanqiong Pan1,2,3,8, Shilin Dai1,2, Fang Fang1,2,3, Jin Zhao5, Shengjin Liu1,2,3★★ Corresponding author

    1. 1Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, CHINA.
    2. 2Department of Chinese Medicine Study, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, CHINA.
    3. 3Chinese Medicine Teaching and Research Office, School of Pharmacy, Jiangsu Health Vocational College, Nanjing, CHINA.
    4. 4Chemistry and Biomedicine Innovation Center (Chem BIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, CHINA.
    5. 5Department of Basic Geological Survey, Jiangsu Geological Bureau, Geological Survey of Jiangsu Province, Geological Society of Jiangsu Province, Nanjing, CHINA.
    6. 6Department of Pharmacy, Jiangsu College of Nursing, Huai’an, CHINA.
    7. 7Department of Pharmacy, Taikang Xianlin Drum Tower Hospital, Nanjing, CHINA.
    8. 8Department of Pharmacy, Taikang Xianlin Drum Tower Hospital, Nanjing, China.

    CORRESPONDENCE

    Shengjin Liu

    Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, CHINA.

    lsj@njucm.edu.cn

    Received: 27-09-2023; Accepted: 28-11-2023.

    Volume 20, Issue 3 · pp. 802–816 · PUBLISHED 2024 · DOI: 10.1177/09731296231221632

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Epilepsy is a neurological disease, and its clinical treatment presents a significant medical challenge. Nevertheless, Chloriti Lapis (CL), a traditional Chinese Mineral Medicine, has been employed for centuries to address neurological disorders and has shown notable effectiveness. Objectives: The objectives of this study are to further explore whether CL can modulate the abundance and diversity of the small intestinal flora in rats with epilepsy induced by pentylenetetrazol (PTZ) and to investigate the interrelationship among the flora. Materials and Methods: Operational taxonomic units (OTUs), α diversity, β diversity, hierarchical clustering tree, and principal component analysis (PCA) were utilized to analyze the small intestinal flora of PTZ-kindled epileptic rats. Results: The predominant bacterial groups in the small intestine mainly belonged to the phyla Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes. The administration of CL was found to effectively increase the abundance and diversity of the small intestinal flora, modify its structural composition, reduce the relative abundance of PTZ-elevated microflora, and enhance the abundance of Streptococcus, Staphylococcus, and Gemella Berger. Conclusion: CL exhibits promising potential, reliability, and unique value in managing epilepsy through the regulation of intestinal flora.

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      Yuan, P., Li, F., Qian, X., Ma, Y., Wang, X., Zhao, Q., Zhu, X., Yan, B., Zhou, L., Yang, W., Pan, Y., Dai, S., Fang, F., Zhao, J., & Liu, S. (2024). Effects of Mineral Chinese Medicine Chloriti Lapis on Gut Microbiota of Small Intestine in PTZ-kindling Epileptic Rats. Pharmacognosy Magazine, 20(3), 802–816. https://doi.org/10.1177/09731296231221632