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    Article

    Therapeutic Alleviation and Mechanism of Glabridin Liposome on Histamine-induced Atopic Dermatitis

    Yongjie Lu1, Lushi Cheng1, Lu Ren1, Dongqiu Chen1, Shumin Guan1, Siyang Zhu1, Xian Xu1, Bing Zhang1,2★, Minghui Tang1, Chijian Zhang1, Yong Ai1, Lanyue Zhang1,2, Tinggang He1★ Corresponding author

    1. 1Hua An Tang Biotech Group Co., Ltd., Guangzhou, Guangdong, China.
    2. 2Guangdong He Ji Biotech Co., Ltd., Guangzhou, CHINA.
    3. 3Current Affiliation: School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.

    CORRESPONDENCE

    Bing Zhang

    Hua An Tang Biotech Group Co., Ltd., Guangzhou, Guangdong, China Corresponding author: Lanyue Zhang, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China. . Email: zhanglanyue@gdut.edu.cn

    zhanglanyue@gdut.edu.cn

    Received: 09-11-2023; Accepted: 29-11-2023.

    Volume 20, Issue 3 · pp. 853–862 · PUBLISHED 2024 · DOI: 10.1177/09731296231225512

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: One of the primary flavonoids found in the Glycyrrhiza glabra is called glabridin, which has anti-inflammatory, anti-bacterial, and antineoplastic effects. However, the insolubility of glabridin in water limits its application. Liposomes can increase the solubility of insoluble drugs and improve their bioavailability. Objectives: We examined the potential for the treatment of glabridin liposomes on histamine-induced atopic dermatitis. Materials and Methods: After GL treatment, histopathology, inflammatory cytokines, and atopic dermatitis-related proteins were used to evaluate the therapeutic effect of GL. Results: Glabridin liposomes alleviated histamine-induced scratching behavior; reduced mast cell proliferation, infiltration, and degranulation; and restrained the expression of associated pro-inflammatory cytokines. Additionally, glabridin liposomes restored nerve growth factor to normal levels and enhanced the expression of filaggrin to promote cuticle growth and repair skin damage caused by atopic dermatitis. Conclusion: Glabridin liposomes may relieve histamine-induced skin hypersensitivity and cortical hyperplasia by inhibiting the production of inflammatory cytokines, demonstrating their potential for the clinical treatment of atopic dermatitis.

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      Lu, Y., Cheng, L., Ren, L., Chen, D., Guan, S., Zhu, S., Xu, X., Zhang, B., Tang, M., Zhang, C., Ai, Y., Zhang, L., & He, T. (2024). Therapeutic Alleviation and Mechanism of Glabridin Liposome on Histamine-induced Atopic Dermatitis. Pharmacognosy Magazine, 20(3), 853–862. https://doi.org/10.1177/09731296231225512