Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β- TCF21 Signaling Pathway
Meng Huo1, Jingjing Lin1, Qiaoqiao Xu1, Haina Zhang1, Qizhen Ye1★★ Corresponding author
- 1Pharmaceutical Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
CORRESPONDENCE
Qizhen Ye
Pharmaceutical Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Received: 21-11-2023; Accepted: 06-02-2024.
Volume 20, Issue 3 · pp. 965–972 · PUBLISHED 2024 · DOI: 10.1177/09731296241239152
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ABSTRACT
Background: Atherosclerosis (AS) is the pathological basis of acute myocardial infarction, acute stroke, and other acute critical illnesses. Vascular smooth muscle cell (VSMC) phenotypic transformation plays a remarkable role in the occurrence and development of AS. Previous studies have found that GSK3β-TCF21 is a key signaling pathway regulating VSMC phenotypic transformation. Baicalin is an important herbal monomer for cardiovascular protection, but whether it can regulate the GSK3β-TCF21 signaling pathway and VSMC phenotypic transformation remains unclear. Purpose: The study aimed to explore the role of Baicalin in AS and VSMC phenotypic transformation and whether the GSK3β-TCF21 signaling pathway participates in this process. Materials and Methods: In this study, through the AS mouse model and ox-LDL-induced VSMC phenotypic transformation model in vitro, the effect of Baicalin on the GSK3β-TCF21 signaling pathway and VSMC phenotypic transformation was investigated. Results: Pathological staining showed that the AS plaque area of the Baicalin group decreased significantly (p < 0.001). The expression of the marker gene (TAGLN, ACTA2, CNN1, and MYH11) of VSMC phenotypic transformation was significantly increased (p < 0.001) after Baicalin treatment. Baicalin could activate GSK3β and increase the expression of TCF21 significantly (p < 0.001) to inhibit VSMC phenotypic transition. Inhibiting the GSK3β-TCF21 signaling pathway was able to reduce the effects of Baicalin on reducing VSMC phenotypic transition and protecting AS. Conclusion: Our study indicates that Baicalin is protective in inhibiting VSMC phenotypic transformation and ameliorating AS by regulating GSK3β-TCF21.
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Huo, M., Lin, J., Xu, Q., Zhang, H., & Ye, Q. (2024). Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β- TCF21 Signaling Pathway. Pharmacognosy Magazine, 20(3), 965–972. https://doi.org/10.1177/09731296241239152