Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    The Vasodilator Effect and Mechanism of 18β-glycyrrhetinic Acid on Isolated Pulmonary Artery Rings in Rats

    Huijuan Yang1, Hailong Li2, Yuxin Liu3, Jinrui Jiang1, Mei Hai1, Cong Li1, Zhiqiang Hu4, Ru Zhou1,5,6,7★★ Corresponding author

    1. 1Ningxia Characteristic Traditional Chinese Medicine Modernization Engineering Technology Research Center, Ningxia Medical University, Yinchuan, Ningxia, CHINA.
    2. 2Key Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia, CHINA.
    3. 3NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, Ningxia, CHINA.
    4. 4Oncology Hospital, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, CHINA.
    5. 5Department of Hygiene Toxicology, School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, CHINA.
    6. 6Department of Respiratory Medicine, Ningxia Hospital of Integrated Traditional Chinese and Western Medicine, Yinchuan, Ningxia, CHINA.
    7. 7Department of Pharmacology, College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia, CHINA.

    CORRESPONDENCE

    Ru Zhou

    Ningxia Characteristic Traditional Chinese Medicine Modernization Engineering Technology Research Center, Ningxia Medical University, Yinchuan, Ningxia, CHINA.

    hzqpty@163.com

    Received: 01-11-2023; Accepted: 06-02-2024.

    Volume 20, Issue 3 · pp. 996–1004 · PUBLISHED 2024 · DOI: 10.1177/09731296241241115

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The purpose of this study was to evaluate the effect of 18β-glycyrrhetinic acid (18β-GA) on isolated rat pulmonary artery vascular rings as well as the mechanism that lies behind the diastolic effects of this compound. Materials and Methods: To examine the effects of various doses of 18β-GA on resting normal vascular rings, we used isolated rat pulmonary artery vascular rings. The isolated rat pulmonary artery vascular ring was precontracted with phenylephrine (PE) and potassium chloride solution (KCl), which allowed for the observation of the diastolic effects of 18β-GA, as well as the effects of various concentrations of 18β-GA on blocking the four potassium channels of glibenclamide, barium chloride (BaCl2), tetraethylamine (TEA), or 4-aminopyridine; the impact of various 18β-GA concentrations on the pulmonary artery vasodilation effect pre-use of the nitric oxide synthase inhibitors l-nitroarginine methyl ester and indomethacin. Results: It was shown that 18β-GA has concentration-dependent diastolic effects on isolated rat pulmonary vascular rings that have been precontracted with PE and KCl but it has no effect on resting isolated thoracic aortic vascular rings. Conclusion: The two Kir and Kv channels may be connected to the endothelium-dependent vasodilation mechanism of 18β-GA.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Yang, H., Li, H., Liu, Y., Jiang, J., Hai, M., Li, C., Hu, Z., & Zhou, R. (2024). The Vasodilator Effect and Mechanism of 18β-glycyrrhetinic Acid on Isolated Pulmonary Artery Rings in Rats. Pharmacognosy Magazine, 20(3), 996–1004. https://doi.org/10.1177/09731296241241115