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    Article

    Eriocitrin in the Treatment of Diabetic Nephropathy: Amelioration Against Oxidative Burst and Inflammation Approach

    Hui Deng1, Yarong Li2, Shulan Han3, Min Lan4, Liqin Cui5, Tahani Awad Alahmadi6, Sulaiman Ali Alharbi7, Zhong Li8★★ Corresponding author

    1. 1Danyang First Aid Command Center, Danyang City, Jiangsu, China
    2. 2Department of Endocrinology, Wuhan Central Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China
    3. 3Department of Pharmacy, Zhucheng Maternal and Child Health Care Hospital, Zhucheng, Shandong, China
    4. 4Department of Endocrinology, Handan First Hospital, Handan, Hebei, China
    5. 5Department of Endocrinology, Aerospace Central Hospital, Beijing, China
    6. 6Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    7. 7Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
    8. 8Department of Nephrology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China

    CORRESPONDENCE

    Zhong Li

    Department of Nephrology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

    18683938815@sina.cn

    Received: 15-12-2023; Accepted: 19-12-2023.

    Volume 20, Issue 4 · pp. 1128–1140 · PUBLISHED 2024 · DOI: 10.1177/09731296241242862

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Diabetes mellitus (DM) induces hyperglycemia and oxidative stress in the kidneys and may cause kidney dysfunction. Diabetic nephropathy (DN) is a prolonged problem of DM with limited treatment. Purpose: In this work, we planned to investigate the beneficial effects of eriocitrin, a natural flavanol found in citrus fruits, against DM-induced DN in rats. Materials and Methods: For the induction of DN, animals were fed a high-fat diet and were administered with streptozotocin (35 mg/kg). After induction, eriocitrin (50 or 100 mg/kg) was administered to the DM rats, and their changes in feed intake, body weight, blood glucose levels, and blood samples were monitored on a daily basis. The oxidative stress markers were estimated by using standard protocols. The renal function markers such as the activity of lactate dehydrogenase (LDH), creatinine, and blood urea nitrogen levels were investigated by using kits. The kidney injury molecule (KIM-1) and pro-inflammatory markers were determined by using commercial kits. The kidney tissues were studied histopathologically. Results: Eriocitrin considerably reduced the body weight and food consumption in DM-induced rats. Furthermore, eriocitrin restored the values of biochemical parameters such as glucose, glycated hemoglobin, urea, creatinine, LDH, serum cholesterol, and triglycerides to near-normal levels. Moreover, the antioxidant properties of eriocitrin markedly suppressed the oxidative and inflammatory markers by continuing the antioxidant/reactive oxygen species balance. Furthermore, the biochemical parameters are well correlated with histopathological examination. Conclusion: Our results provide valuable scientific information, that supports the therapeutic role of eriocitrin and its protective effects in DM and its complications (DN).

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      Deng, H., Li, Y., Han, S., Lan, M., Cui, L., Alahmadi, T. A., Alharbi, S. A., & Li, Z. (2024). Eriocitrin in the Treatment of Diabetic Nephropathy: Amelioration Against Oxidative Burst and Inflammation Approach. Pharmacognosy Magazine, 20(4), 1128–1140. https://doi.org/10.1177/09731296241242862