Volume 20, Issue 4

2024 · pp. 1031–1380 · 32 articles

Volume: 20
Issue: 4
Published: 2024
Pages: 1031–1380
Articles: 32
Sections: 2
ISSN: ISSN: Print - 0973-1296, Online - 0976-4062
Journal: Pharmacogn. Mag.

Review Article Original Research Article

In this issue

Review Article

Review
Chronic Liver Disease and Promising Therapeutic Strategy: A Concise Review
Han Yu, Zhijun Wang, Gang Zhao
pp. 1031–1047 · DOI: 10.1177/09731296241228361 · Published 2024
Background: Chronic liver dysfunction (CLD) is a significant global health issue; alcohol use, obesity, drugs, and antibiotic and viral infections contribute to its development. However, changes in gut microbiota composi…
Review
Antidiabetic Phytoconstituents: From Traditional Medicine to Modern Drug Discovery
Mohammed Albratty, Maryam Halawi
pp. 1048–1060 · DOI: 10.1177/09731296241247606 · Published 2024
Background: The simplest form of carbohydrate that the human body can utilize efficiently to fuel various functions in our body is glucose. The food that is consumed by us in any form is acted upon by pancreatic juices, …
Review
Targeting Intrinsic and Extrinsic Pathways of Ferroptosis: A Novel Anticancer Strategy of Curcumin
Wei Hao, Yuan Gao, Bangwei Cao
pp. 1061–1070 · DOI: 10.1177/09731296241251957 · Published 2024
Background: The turmeric rhizome yields a medicinal compound called curcumin. Curcumin’s anticancer methods mostly involve blocking cell invasion and proliferation, controlling gene expression, preventing angiogenesis, t…
Review
Applications and Mechanisms of Taohong Siwu Decoction in the Treatment of Ischemic Stroke
Runjia Liu, Yanqing Li, Xiaochen Zhang, Kaixuan Tang, Jiatong Li, Tianhe Fang, Xuanhe Tian, Bingbing Han
pp. 1071–1085 · DOI: 10.1177/09731296241235435 · Published 2024
Ischemic stroke is a kind of sudden vascular disease of the brain brought on by ischemic hypoxic necrosis of the brain tissue which is becoming a significant global source of death and long-term impairment. Present commo…

Original Research Article

Article
Fraxinus excelsior L. for Prevention of Capecitabine-induced Enterocolitis in Rat: An Integrated Biochemical, Molecular, and Histopathological Study
Li Li, HaiYan Tan, TianLu Su
pp. 1086–1099 · DOI: 10.1177/09731296241244561 · Published 2024
Background: Chemotherapy drugs damage intestinal cells, weakening the intestinal barrier. This damage results in higher permeability, which enables bacteria and toxins to enter the intestinal tissue. Purpose: This study …
Article
Lijing-Anfei Decoction Attenuates COPD in a Mouse Model: Network Pharmacology Analysis, Molecular Docking, and Experimental Validation
Jiajia Zhu, Jie Liu, Wei Jia, Guoqiang Shao, Haizhu Xu
pp. 1100–1113 · DOI: 10.1177/09731296241242909 · Published 2024
Background: Today, network pharmacology and molecular docking were utilized for investigation and prediction of possible mechanisms in fields such as pharmacognosy and traditional Chinese medicine formulas when treating …
Article
Anticancer Effects of Vaccinium arctostaphylos L. through HOTAIR/miR-124/Notch1 Axis of Hepatocellular Carcinoma in Rat: A Biochemical, Molecular, Immunohistochemical, and Histopathological Approaches
Chengchen Zhou, Xiaoling Qin, Jingyi Wang, Yongchang Liu
pp. 1114–1127 · DOI: 10.1177/09731296241264620 · Published 2024
Background and Purpose: We investigated the effectiveness of Vaccinium arctostaphylos L. fruit extract (VAFE) in protecting hepatocytes against N-diethylnitrosamine (DEN)-related hepatocellular carcinoma (HCC) by explori…
Article
Eriocitrin in the Treatment of Diabetic Nephropathy: Amelioration Against Oxidative Burst and Inflammation Approach
Hui Deng, Yarong Li, Shulan Han, Min Lan, Liqin Cui, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Zhong Li
pp. 1128–1140 · DOI: 10.1177/09731296241242862 · Published 2024
Background: Diabetes mellitus (DM) induces hyperglycemia and oxidative stress in the kidneys and may cause kidney dysfunction. Diabetic nephropathy (DN) is a prolonged problem of DM with limited treatment. Purpose: In th…
Article
Aqueous Extract of Pinellia ternata Breitenbach Tuber Ameliorates Bilateral Common Carotid Artery Stenosis-Induced Cognitive Deficit in Mice by Suppressing the Activation of Astrocytes
Kyong-Lim Kim, Chiyeon Lim, Sehyun Lim, Suin Cho, Kyung-Min Kim
pp. 1141–1153 · DOI: 10.1177/09731296241242211 · Published 2024
Background: The proportion of dementia patients in Asian countries is rapidly increasing, and because vascular dementia is more common than in the West, it is recognized as important as Alzheimer’s disease. Purpose: The …
Article
Lentinan Regulates Glioma Cell Proliferation and Apoptosis by Activating p53 and Caspases Pathways
Ying Sun, Peng Gao, Xilin Wan, Xinze Liu, Fang Xu, Jiaqi Wang
pp. 1154–1166 · DOI: 10.1177/09731296241253125 · Published 2024
Background: Gliomas are highly lethal malignancies that develop in the central nervous system. The primary treatment for gliomas involves surgical resection followed by chemoradiotherapy. However, due to the infiltrative…
Article
Molecular Targets and Mechanisms of Poria cocos-Licorice Drug Pair for the Treatment of Henoch–Schönlein Purpura Nephritis Based on Network Pharmacology
Jiahua Liu, Qingqing Liu, Xiaoqin Ma, Weiyan Guo, Jie Mi
pp. 1167–1178 · DOI: 10.1177/09731296231223839 · Published 2024
Background: The herbal Poria cocos-Liquorice drug pair (PLDP) possesses the ability to be a diuretic, stimulating the spleen and benefiting the kidney, which plays an important role in the treatment of Henoch–Schönlein p…
Article
Research Progress on Inhibition of Osteoclast Differentiation by Traditional Chinese Medicine
Yanan Qian, Siomui Chong, Qian Chen, Chengliang Yin, Yujing Cao
pp. 1179–1190 · DOI: 10.1177/09731296241228904 · Published 2024
Background: Bone tissue undergoes continuous remodeling to maintain a steady state of bone equilibrium. During this process, osteoblasts actively stimulate bone formation, while osteoclasts continuously engage in bone re…
Article
Extraction, Purification, and in vitro Antioxidant Activity Assessment of Total Flavonoids from the Aerial Parts of Tetrastigma hemsleyanum
Chong-lu Sun, Yu-jiong Zhang, Song-lin Yu, Shi-min Li, Xiao-yu Hu, Jin-long Xu
pp. 1191–1202 · DOI: 10.1177/09731296241242176 · Published 2024
Background: The effective extractives of Tetrastigma hemsleyanum (T. hemsleyanum) are useful, but this plant was not fully utilized in rural China. In this study, flavonoids from the aerial parts of T. hemsleyanum were e…
Article
Aqueous Extract of Terminalia bellirica Fruits Improves Insulin Sensitivity, Controls Hyperglycaemia and Improves SIRT1 Expression in High-fat Diet and Streptozotocin-induced Type 2 Diabetes in Rats
Ojaskumar D. Agrawal, Yogesh A. Kulkarni
pp. 1203–1214 · DOI: 10.1177/09731296241238852 · Published 2024
Background: Plants from the genus “Terminalia” are well known for their various pharmacological and medicinal properties. Terminalia bellirica is considered a vital medicinal plant from the genus Terminalia. It has been …
Article
The Hepatoprotective Effect of Trigonelline in Diabetic Rat through Insulin-related IRS1- GLUT2 Pathway: A Biochemical, Molecular, Histopathological, and Immunohistochemical Study
Meizhi Li, Shiqing Li, Shanshan Jiang, Weihong Li
pp. 1215–1225 · DOI: 10.1177/09731296241247365 · Published 2024
Background: Diabetes significantly increases morbidity and mortality rates, causing complications such as cardiovascular disease, kidney failure, and blindness. Purpose: The aim of this study was to investigate the hepat…
Article
Effects of Tanshinone IIA on Cognitive Impairment in Alzheimer’s Disease Rats Via Oxidative Stress, Inflammatory Responses and Apoptosis
Wujiang Ren, Xiaoxiao Li, Tingqiao Wang, Yanxia Liu, Xueling Dai, Qing Huo, Shuo Wang, Qiusheng Zheng, Yaxuan Sun
pp. 1226–1236 · DOI: 10.1177/09731296241246632 · Published 2024
Background: The rationale for the pathogenesis of Alzheimer’s disease (AD) is the production of amyloid-beta (Aβ) and its resultant toxic effects. Purpose: In this work, rats with AD were used as models to assess the mod…
Article
Schisandrol A Relaxes the Rat Trachea Via L-Type Ca2+ Channels and KV Channels
Zhiying Xu, Chengcheng Lin, Jinghui Sun, He Li, Wenyue Zhuang, Jianguang Chen, Chunmei Wang, Haili Wang
pp. 1237–1247 · DOI: 10.1177/09731296241253896 · Published 2024
Background: Schisandra chinensis is widely applied in the prevention and treatment of asthma in China, but the material basis for the anti-asthmatic effect of S. chinensis is unclear. Our previous studies found that the …
Article
Aridanin Attenuates Behavior Deficits and Neuroinflammatory Response in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s Disease in Mice
Weigu Ban, Lina Lu, Xiuying Teng, Yiran Zhang, Hui Qi
pp. 1248–1257 · DOI: 10.1177/09731296241251916 · Published 2024
Background: Parkinson’s disease (PD), the second most prevalent neurological illness, is treated with pharmacologic and nonpharmacologic techniques, including medicinal plants and their extracts. Purpose: We assessed the…
Article
Punicalagin Ameliorating Renal Cell Tumors Against N-Diethylnitrosamine-initiated Iron Nitrilotriacetate-induced Carcinogenesis
Li Li, Lin Liu, Hong Qin, Ligang Xing
pp. 1258–1267 · DOI: 10.1177/09731296241255436 · Published 2024
Background: Renal cell carcinoma, the most prominent kind of adult kidney cancer, lacks early warning symptoms, leading to metastases at the time of diagnosis. Renal cell carcinoma begins with N-diethylnitrosamine (DEN) …
Article
A Comparative Study on Antibacterial Activities of Alcohol Disinfectants and α-Mangostin Extract
Mohammed Sohel Meah, Pharkphoom Panichayupakaranant, Kris John Silvano, Rakhimov Abdurakhim Ramazon Ugli, Min Gab Kim
pp. 1268–1275 · DOI: 10.1177/09731296241262569 · Published 2024
Background: A green and efficient process, free from toxic solvents, was employed to prepare an α-mangostin-rich extract. Conventional techniques like maceration and heat reflux extraction are recognized for their time-i…
Article
Astilbin Inhibits the Proliferation and Induces Apoptosis of Gastric Cancer Cells (AGS) by Targeting the Key Inflammatory Markers
Guoshan Zhang, Xiaoyuan Zhuang, Shen Lin, Yatian Wang
pp. 1276–1285 · DOI: 10.1177/09731296241264612 · Published 2024
Background: The predisposition toward gastrointestinal disease is increasing as a result of dietary changes and overindulgence in food preparation. Ninety percent of stomach cancers are adenocarcinomas, a type of cancer …
Article
Exploring Melezitose as a Potential Therapeutic Agent in Lung Cancer: Inhibitory Effects on Cell Proliferation and EMT-Mediated Signaling in A549 Cells
Qihui Zhou, Ziyong Wu, Xi Cheng, Zhigang Zuo, Cunyu Fan
pp. 1286–1294 · DOI: 10.1177/09731296241251545 · Published 2024
Background: Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-related deaths. The study delves into melezitose, a naturally occurring compound known for its biocompatibility. Purpose: …
Article
Tibetan-Origin Edible Chinese Herbal Prescription C18 Protects H9C2 Cardiomyocytes from Cobalt Chloride-induced Hypoxia Injury through the PI3K/AKT Signaling Pathway
Guoxin Chang, Hongyi Xie, Shu Chen, Ruixue Wang, Xuxin Zeng, Dingmei Lin, Zixuan Mo, Jingjing Yu, Xindan Liu, Zhaoguang Zheng, Yan Wang
pp. 1295–1303 · DOI: 10.1177/09731296241252202 · Published 2024
Background: Altitude sickness is often prone to occur during tourism or work in high-altitude areas. In China, traditional Tibetan medicines have a long history of preventing or treating altitude sickness, especially alt…
Article
Kaempferide Inhibits DOX-induced Liver Inflammation by Activating AMPKα/SIRT1
Qiang Li, Xing Li, Zhenchang Zhou, Pingwei Zhu, Nana Tuo, Jingli Ge, Zhaoyv Liu, Dengke Chen
pp. 1304–1312 · DOI: 10.1177/09731296241228923 · Published 2024
Objectives: DOX can promote liver cell inflammation and lead to liver cell death. Ka protects and stabilizes liver cells for the treatment of hepatitis, cirrhosis, and other diseases. However, there is no evidence to sug…
Article
Nerolidol Alleviates Oxidative Stress and Inflammation in Diabetic Retinopathy Mediated by High Glucose through Ameliorating Nrf2/HO-1 Pathway
Changhong Li, Buchao Shi, Dong Li, Hui Li
pp. 1313–1321 · DOI: 10.1177/09731296241247922 · Published 2024
Background: Diabetic retinopathy (DR) is the foremost microvascular problem that causes drastic visual impairment in diabetes patients. Hyperglycemia-triggered reaction cascade of inflammation and oxidative stress consti…
Article
Anti-myocardial Ischaemia by Bioinformatics of Apocynum venetum L.
Yuan-Jia Yue, Yu Li, Xing Rong, Zhao Ji, Hui-Min Wang, Lin Jiang
pp. 1322–1330 · DOI: 10.1177/09731296241242178 · Published 2024
Background: In recent years, the number of patients with myocardial ischaemia is rising year by year in China. Objectives: The study uses network pharmacology to predict targets and pathways of action of Apocynum venetum…
Article
Investigating the Anti-adipogenic Potential of Xanthium strumarium Linn. Leaves Fractions: HPTLC-MS Characterization, Enzymatic Analysis, and 3T3-L1 Adipocyte Differentiation Assay in Oxidative Stress-modulated Adipogenesis Cascade
Nikita Nayak, Ashok Pattnaik
pp. 1331–1340 · DOI: 10.1177/09731296241242842 · Published 2024
Background: Molecular pathogenesis of obesity is initiated by cellular oxidative stress along with increased adipogenesis. For the search of better alternatives of synthetic molecules in terms of their adverse events, na…
Article
Effects of Different Administration Cycles of Rhubarb on Fecal Metabolism in Healthy Rats Based on Metabolomics
Rui Chen, Hongmei Su, Jing Bai, Xueqing Duan, Guo Feng, Weiyi Tian
pp. 1341–1349 · DOI: 10.1177/09731296241245179 · Published 2024
Background: Rhubarb is a common cold-property drug that is commonly used as an effective laxative. It was first recorded in Shen Nong’s Herbal Classic. Purpose: The LC-MS/MS metabolomics technology was used in this study…
Article
Unraveling the Pharmacological Intricacies of Kurarinone in Osteoporosis: Insights from a Network Pharmacology Approach
Zhongyu Xiong, Huawen Yang
pp. 1350–1358 · DOI: 10.1177/09731296241259563 · Published 2024
Background: Kurarinone, a compound derived from Sophora flavescens, has been widely studied for its anti-inflammatory properties, as well as its potential in treating autoimmune encephalomyelitis and inflammation-related…
Article
Huanglian Jiedu Decoction Inhibits LPS-induced Neuroinflammation and Attenuates the Activation of NLRP3 Inflammasome in BV2 Cells
Junli Wang, Rui Wang, Yaming Du, Xinzi Xu, Xin Liu, Wei Shao, Guohua Chen
pp. 1359–1366 · DOI: 10.1177/09731296241244575 · Published 2024
Background: Huanglian Jiedu decoction (HLJDD) is a classical herbal formula for treating inflammatory diseases with Traditional Chinese Medicine (TCM). However, the impacts of HLJDD on neuroinflammation and the precise m…
Article
Luteolin Ameliorates Non-alcoholic Fatty Liver Disease via Regulation of Hepatic Lipid Uptake, Autophagy, and Apoptosis in WD/CCl4-induced Mice
Jingjing Hu, Dongyue Pang, Ning Tian, Rongyin Qin
pp. 1367–1373 · DOI: 10.1177/09731296241258540 · Published 2024
Background and Purpose: Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem with high prevalence and morbidity associated with obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and dyslipi…
Article
Study on UPLC–MS/MS Method for Four Compositions of Cangzhu
Ren Qiyong, Sun Jikai, Qin Lili, Zhang Min, Ma Junying, Liu Jun, Zhang Honglian
pp. 1374–1379 · DOI: 10.1177/09731296241251534 · Published 2024
Background: The legal quality control of Cangzhu is used the single component as an evaluation indicator, which would not be enough to reflect the authenticity of quality. It is necessary to select several typical chemic…