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    Article

    Sanggenol L Reduces LPS-induced Myocardial Injury and Inflammation by Activating PI3K/ AKT/mTOR and Inhibiting NF-κB in Rats

    Haojun Wang1, Tao Jin2, Yuehan Mao3, Yi Wei4★★ Corresponding author

    1. 1Department of Emergency Medicine, Shanghai Gongli Hospital, Shanghai, China.
    2. 2Department of Intensive Care Unit, Huaian Hospital of Huaian City, Huaian, Jiangsu, China.
    3. 3Department of Outpatient, The General Hospital of Western Theater Command of Chinese People’s Liberation Army, Chengdu, Sichuan, China.
    4. 4Department of Intensive Care Unit, Xuzhou New Health Hospital, Xuzhou Cancer Hospital North Hospital, Xuzhou, Jiangsu, China.

    CORRESPONDENCE

    Yi Wei

    Department of Intensive Care Unit, Xuzhou New Health Hospital, Xuzhou Cancer Hospital North Hospital, Xuzhou, Jiangsu, China.

    onlywei1987@sina.cn

    Received: 16-02-2024; Accepted: 06-06-2024.

    Volume 21, Issue 2 · pp. 443–453 · PUBLISHED 2025 · DOI: 10.1177/09731296241264617

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The manifestation of severe sepsis is sepsis-induced myocardial dysfunction (SIMD), which is the chief cause of elevated death in sepsis patients. Sepsis mainly attacks the heart, and the effective switch of the inflammatory cascades is of prodigious implication in relieving sepsis-allied myocardial impairments. Natural antioxidants with anti-inflammatory and antiapoptotic properties are promptly required as typical anti-septic agents. Objectives: Morus alba root bark contains a flavonoid sanggenol L (SL), which exhibits antioxidant, apoptotic, and antiinflammatory activities. Nevertheless, the anti-septic action of SL has not yet been described. Hence, we explored the antioxidative, antiapoptotic, and anti-inflammatory actions of SL on lipopolysaccharide (LPS)-triggered sepsis in rats. Materials and Methods: Rats were divided into four sets: group 1: control, group 2: LPS (20 mg/kg bw), group 3: LPS (20 mg/kg bw) + dexamethasone (2 mg/kg bw), and group 4: LPS (20 mg/kg bw) + SL (10 mg/kg bw). We assessed cardiotoxicity, antioxidants, cytokines, histopathology, protein expressions of apoptosis, and inflammatory enzymes. Results: Data unveiled that SL inhibited toxicity markers, oxidative stress, inflammation, apoptosis, and histological changes. SL effectively attenuated LPS-induced acute myocardial injury by stimulating the PI3K/AKT/mTOR signaling and suppressing the nuclear factor kappa B (NF-κB) pathway. Conclusion: Thus, SL might be a possible anti-septic agent for the treatment of SIMD.

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      Wang, H., Jin, T., Mao, Y., & Wei, Y. (2025). Sanggenol L Reduces LPS-induced Myocardial Injury and Inflammation by Activating PI3K/ AKT/mTOR and Inhibiting NF-κB in Rats. Pharmacognosy Magazine, 21(2), 443–453. https://doi.org/10.1177/09731296241264617