Volume 21, Issue 2

2025 · pp. 323–717 · 33 articles

Volume: 21
Issue: 2
Published: 2025
Pages: 323–717
Articles: 33
Sections: 2
ISSN: ISSN: Print - 0973-1296, Online - 0976-4062
Journal: Pharmacogn. Mag.

Review Article Original Research Article

In this issue

Review Article

Review
The Application of Ficus Species in the Treatment of Neurological Disorders
Adib Alam, Papiya Mitra Mazumder
pp. 323–335 · DOI: 10.1177/09731296241281440 · Published 2025
Background: Neurological diseases represent a pressing global health concern; the World Health Organization reports that neurological conditions rank as the second leading cause of death worldwide. In the last quarter ce…
Review
Research Progress of Traditional Drug Therapies for Nasopharyngeal Carcinoma by the PI3K/AKT Signaling Pathway
Qiong Fang, Junjie Wang, Tingting Wu, Yining Cai, Huimin Wang, Jitang Cai
pp. 336–347 · DOI: 10.1177/09731296241286282 · Published 2025
Background: Nasopharyngeal carcinoma (NPC) is an uncommon type of epithelial carcinoma, characterized by unique features and a higher prevalence in certain populations. Traditional medicines are commonly employed in the …
Review
A Review of a Traditional Chinese Medicine Formula for Treating Insomnia with Depression: Wendan Decoction
Lingyuan Kong, Xinyi He, Xiuyang Li
pp. 348–363 · DOI: 10.1177/09731296241246313 · Published 2025
Background: The relationship between insomnia and depression is complex and two-way. Long-term insomnia may cause, maintain, and aggravate depression, and with the development of the disease, depression patients will als…
Review
Phytochemistry and Pharmacological Activities of Panax japonicus: A Comprehensive Review
Li Wang, Ao-jia Zhou, Yi-dan Zhang, Cheng Fan, Shan-shan Hu, Zhi-yong Zhou, Ding Yuan, Ting Wang
pp. 364–379 · DOI: 10.1177/09731296241259807 · Published 2025
Background: Panax japonicus (P. japonicus) belongs to the Panax genus of Araliaceae and is used as medicine mainly with the bamboo whiplike rhizome, which has the functions of dispelling blood stasis and hemostasis, atte…
Review
Regulations of Immune Response by Astragalus in Animal Asthma Models: A Meta-analysis
Song Wang, Xinhua Chen, Zuoqiao Shi, Qianqian Shen, Jing Li, Wang Hua, Wang Shujing, Wanjing Wu, Qing Xi, Guowen Li
pp. 380–393 · DOI: 10.1177/09731296241276582 · Published 2025
Background: Asthma is a chronic respiratory condition by airway inflammation. Traditional Chinese Medicine, is commonly used to treat it. Astragalus is known for its immunoregulation, anti-inflammatory, and antioxidant e…
Review
Research Progress in the Treatment of Depression by Acupuncture and Moxibustion Based on the Five Viscera and its Mechanism
Ruisu Zhang, Qian Zhang, Dandan Zhang, Ning Zhang, Qingwei Li, Chenyang Li, Long Wang
pp. 394–402 · DOI: 10.1177/09731296241305935 · Published 2025
Severe depression is the most common mental disorder, with a heavy economic burden and limited treatment. The lifetime prevalence of depression among adults in China is 6.8%, with depression accounting for 3.4%. Currentl…
Review
Annona squamosa Linn.: A Review of Its Ethnobotany, Pharmacology, Phytochemistry, Toxicity, and Conservation Needs
Ravi Pratap Singh, Ashok Kumar Pattnaik, Mithun Rudrapal, Soumya Bhattacharya
pp. 403–412 · DOI: 10.1177/09731296241281422 · Published 2025
Nature exhibits a unique beauty that is both recognized and integrated into human practices globally. Annona squamosa Linn., commonly known as “sweet sugar,” is a small medicinal shrub cultivated for its fruits. This spe…

Original Research Article

Article
Pinobanksin Attenuates Cerebral Ischemia– Reperfusion Injury in Rats through Mitigating the Inflammatory Responses
Tianmin Bie, Feng Jia, Yongmei Wang, Zhuoyan Pan
pp. 413–422 · DOI: 10.1177/09731296241262561 · Published 2025
Background: Stroke is a collection of disorders that develop due to the rapid rupture of blood vessels in the brain or due to the blockage of blood flow. Ischemic stroke (IS) has high mortality as well as morbidity rates…
Article
Extraction and in vitro and in vivo Antioxidant Activity Evaluation of Polyphenols from Lychee Pericarp
Ying Wang, Hong Deng, Chuqin Yu, Junfeng Ban, Shu Zhang
pp. 423–432 · DOI: 10.1177/09731296241274884 · Published 2025
Background: Finding a new promising plant antioxidant to combat or prevent cardiovascular disease remains a major challenge for researchers. Lychee pericarp, which includes a variety of polyphenols, is a prospective sour…
Article
Discussion about the Role of Ghrelin in Myocardial Ischemia/Reperfusion and its Possible Mechanism
Gang Huang, Nan Zheng, Yinqing Huang
pp. 433–442 · DOI: 10.1177/09731296241275304 · Published 2025
Background: Ghrelin in the gastric mucosa of rats can improve myocardial cell apoptosis and cardiac remodeling during myocardial ischemia and myocardial infarction, and it has a protective effect on the myocardium, but i…
Article
Sanggenol L Reduces LPS-induced Myocardial Injury and Inflammation by Activating PI3K/ AKT/mTOR and Inhibiting NF-κB in Rats
Haojun Wang, Tao Jin, Yuehan Mao, Yi Wei
pp. 443–453 · DOI: 10.1177/09731296241264617 · Published 2025
Background: The manifestation of severe sepsis is sepsis-induced myocardial dysfunction (SIMD), which is the chief cause of elevated death in sepsis patients. Sepsis mainly attacks the heart, and the effective switch of …
Article
Identification of Novel Candidate Targets for Fascaplysin through in silico and in vivo Analyses of Shared Targets among Structurally Similar Compounds
Ki-Hoon Park, Junyang Jung, Na Young Jeong
pp. 454–466 · DOI: 10.1177/09731296241259226 · Published 2025
Background: The discovery of new drug targets is a critical and challenging aspect of drug development. Fascaplysin, a marine natural product, has shown potential in various biological applications, but identifying suita…
Article
Ganoderic Acid A Suppresses Androgenindependent Cell Growth via the AKT/GSK-3β/β-catenin Signaling Pathway
Qiao Lyu, Yuan Qu, Jianfan Chen, Guo Chen, Zheng Chen, Lijun Qu
pp. 467–479 · DOI: 10.1177/09731296241262075 · Published 2025
Objectives: The primary aim of this study is to investigate the specific effects and mechanisms of ganoderic acid A (GAA) on castration-resistant prostate cancer (CRPC). Materials and Methods: We successfully established…
Article
Exploring Obesity Treatment Potential of Neolamarckia cadamba Bioactive Fraction: A Multifaceted Investigation Combining in vitro, 3T3-L1 Adipogenesis Differentiation, and HPTLC–MS Techniques to Identify Lead Compounds
Shivangi Kumari, Ashok Kumar Pattnaik
pp. 480–490 · DOI: 10.1177/09731296241264071 · Published 2025
Background: The rising incidence of obesity and its related health issues demand novel approaches prioritizing safety and effectiveness. In light of concern about the side effects of pharmaceutical therapies, research in…
Article
Shilajit (Mumio) Elicits Apoptosis and Suppresses Cell Migration in Oral Cancer Cells through Targeting Urokinase-type Plasminogen Activator and Its Receptor and Chemokine Signaling Pathways
Abdullah Alqarni, Jagadish Hosmani, Raghad Mohammed, Abdullah Alqahtani, Sarah Alasiri, Nasser Alhamid, Hattan Zaki, Thabet Al Housami, Elumalai Perumal, Imran Khalid, Khurshid Mattoo
pp. 491–506 · DOI: 10.1177/09731296241275740 · Published 2025
Background: Shilajit a natural phytomineral has a proven record of treating many human body ailments. Objectives: This study aimed to explore the influence of Shilajit on cell proliferation and apoptosis induction in ora…
Article
New Polysaccharides from Hygrophorus olivaceoalbus (HO-P) and Agrocybe aegerita (AA-P) and their Biological Activities
Tong Yang, Hui Zhao, Xiang Ding, Yiling Hou
pp. 507–520 · DOI: 10.1177/09731296241279087 · Published 2025
Background: Fungal polysaccharides are an essential active polymer compound in human cells. A clear understanding of the structure of polysaccharides is the foundation for conducting research and utilization of polysacch…
Article
Efficacy of Turmeric-Boswellia Formulation for Acute Low Back Pain: A Double-blind, Randomized, Placebo-controlled Trial
Sanjeev Kumar Kare, Ajay Gupta, Girish H. Rudrappa
pp. 521–535 · DOI: 10.1177/09731296241281438 · Published 2025
Objectives: To evaluate the efficiency of the turmeric-Boswellia formulation (TBF, Rhuleave-K) in reducing acute low back pain (LBP) among healthy subjects. Materials and Methods: This research aimed to assess the effect…
Article
Ginsenoside Enrichment and Soil Enhancement via Reductive Soil Disinfection Treatment
Zhefeng Xu, Chunshuo Liu, Yuqiu Chen, Jing Fang, Rui Liu, Tao Zhang, Changbao Chen
pp. 536–549 · DOI: 10.1177/09731296231216173 · Published 2025
Background: Ginseng (Panax ginseng C. A. Meyer) is a type of plant that cannot be continuously cultivated. Continuous cultivation of ginseng can lead to the deterioration of soil properties, affecting the normal growth a…
Article
Chemoprotective Effect of Bryodulcosigenin against 7,12-Dimethylbenz(a)anthracene-induced Breast Cancer via Suppression of Inflammation, Oxidative Stress, and Apoptosis
Jie Zheng, Junyan Hu, Shujun Jiang, Yuhong Wang, Dan Xing
pp. 550–560 · DOI: 10.1177/09731296241281854 · Published 2025
Background: Breast cancer, originating in the cells of the breast, involves a significant role of oxidative stress and inflammatory reactions in tumor cell proliferation. In this study, we investigate the chemoprotective…
Article
The Potential Application of Moringa oleifera Extracts as Natural Preservatives of Chicken Meat
Zimasa Busisiwe Dubeni, Lisa V. Buwa-Komoreng, Siza Mthi
pp. 561–572 · DOI: 10.1177/09731296241288922 · Published 2025
Background: Chicken meat is vulnerable to contamination during processing and storage, leading to spoilage and economic losses. To find natural alternatives to synthetic preservatives, researchers are exploring plant-bas…
Article
Selective Cytotoxicity and Gene Expression Profiles in Response to Methanolic Extract of Phyllanthus amarus Extract against MCF-7 Breast Cancer Cells
Wei Chen, Qing Hong, Jianing Chen, Yinghui Bi
pp. 573–583 · DOI: 10.1177/09731296241285972 · Published 2025
Background: Breast cancer, a malignant tumor, is the most common cancer type among women worldwide. Conventional chemotherapy treatments for breast cancer often cause adverse side effects in normal tissues and can lead t…
Article
Chikusetsusaponin IVa Targets Nrf2 to Inhibit H9N2 Avian Influenza Virus Infection
Qi Dai, Song-Tao Wu, Xin Zheng, Peng-Tao You, Yan-Wen Liu, Yuan Zhao, Xiu-Qiao Zhang
pp. 584–598 · DOI: 10.1177/09731296241277316 · Published 2025
Background: Chikusetsusaponin IVa (CHS) is a triterpenoid saponin that has been demonstrated to possess multiple properties. Objectives: This study focused on inhibiting H9N2 avian influenza virus (AIV) by CHS and invest…
Article
The Effect of Apigenin on Renal Damage Induced by Aristolochic Acid I and the Involvement of Nrf2/HO-1 Pathway
Leyi Ma, Zijiao Quan, Nan Zheng, Ming Lin
pp. 599–607 · DOI: 10.1177/09731296241297733 · Published 2025
Background: Aristolochic acid is naturally found in plants of the Aristolochiaceae family and possesses antitumor, antiinfection, and anti-inflammatory properties. Objectives: This study investigated the protective effec…
Article
GLA-loaded Liposome Albumin Particles-mediated p53 Targets Cervical Cancer Cell Transplant Tumors
Yanzi Du, Chengyun Liu
pp. 608–615 · DOI: 10.1177/09731296241298347 · Published 2025
Background: p53 is a phosphorylated glycoprotein whose expression is abnormally elevated in various human tumors. p53 also regulates a variety of tumor cells, but research on cervical cancer has not yet been reported. Ob…
Article
Effects of Glechoma longituba (Nakai) Kuprian on Motor and Cognitive Functions in a Traumatic Brain Injury Mice Model
Jihye Park, Jang-Hoon Kim, Jinhyun Bae, Seogyeong Lee, Yunseo Lim, Beom-Joon Lee, Jae-Woo Park, Seok-Jae Ko, Kyungjin Lee, Youngmin Bu
pp. 616–625 · DOI: 10.1177/09731296241282408 · Published 2025
Background: Glechoma longituba (Nakai) Kuprian (GL) is primarily used to treat urinary tract infections and traumatic injuries in traditional medicine in East Asia. Various components of GL are reported to show beneficia…
Article
Concanavalin: A Loaded Chitosan Nanoparticles Synthesis and Characterization to Inhibit the Proliferation of Lung Cancer
Na Yang, Ying Chang
pp. 626–638 · DOI: 10.1177/09731296241276584 · Published 2025
Background: Non-small-cell lung cancer is the most ubiquitous malignancy, and the present treatments do not offer the most effective outcomes for therapy. Natural drug therapy, which directly targets tumor cells, is now …
Article
Regulation of Glutamate and γ-Aminobutyric Acid Receptors in Rats with Depression by Sniffing the Essential Oil of Citrus × aurantium L. [Rutaceae]
Guilin Ren, Gang Ke, Qingrong Pu, Jian Zhao, Rui Huang
pp. 639–649 · DOI: 10.1177/09731296241281431 · Published 2025
Background: Modern research has proved that the volatile oil (VO) of Citrus × aurantium L. [Rutaceae] has the effect of treating depression, but the mechanism of treating depression by sniffing has not been studied. Obje…
Article
Uridine-mediated Activation of the Keap1-Nrf2 Pathway for Alleviating Sepsis-induced Acute Lung Injury
Guoping Li, Yalan Hu, Fan Xu, Fei Li
pp. 650–661 · DOI: 10.1177/09731296241275755 · Published 2025
Background: Sepsis-induced pulmonary injury poses a significant challenge in critical care due to its high morbidity and mortality rates. Objectives: This study explores the potential of uridine to mitigate sepsis-induce…
Article
Anti-inflammatory Effects and Toxicity Study of Chemically Characterized Extracts from Juniperus thurifera (L.) and Juniperus phoenicea (L.)
Soufyane Lafraxo, Amira Metouekel, Fatima Ez-Zahra Amrati, Otmane Zouirech, Tarik Chelouati, Aziz Drioiche, Abdel-Rhman Z. Gaafar, Samir Ibenmoussa, Abdulaziz Abdullah Alsahli, Mohammed Bourhia, Abdelfattah El Moussaoui, Amina Bari
pp. 662–672 · DOI: 10.1177/09731296241281500 · Published 2025
Background: Moroccan traditional medicine utilizes Juniperus thurifera and Juniperus phoenicea to treat numerous ailments. Objectives: This research investigates the chemical composition, acute toxicity, and anti-inflamm…
Article
Exploring Fagonia cretica and Berberis lycium as α-Amylase Inhibitors: Potential Therapeutic Strategies for Diabetes Mellitus Investigated through in vitro and in silico Approaches
Yan-Kun Chen, Imtiaz Ahmad, Noor Rahman, Shafiullah Shafiullah, Haroon Khan, Luca Rastrelli, Said Alam, Yousef A. Bin Jardan, Mohammed Bourhia, Changan Jiang
pp. 673–683 · DOI: 10.1177/09731296241286281 · Published 2025
Background: Growing diabetes prevalence prompts investigation into plant-derived compounds’ potential to inhibit α-amylase, offering novel therapeutic avenues for treating diabetes mellitus (DM). Objectives: In the curre…
Article
Phytochemical Analysis and Pharmacological Actives of Essential Oils Extracted from Leaves of Juniperus turbinata Guss.
Mohammed Bourhia, Abdulaziz Abdullah Alsahli, Badiaa Lyoussi, Ahmed Samir Benjelloun
pp. 684–697 · DOI: 10.1177/09731296241281499 · Published 2025
Background: Juniperus turbinata Guss. is a medicinal mountain plant used by the Indigenous population in the traditional pharmacopeia. Objectives: This study aimed at investigating the phytochemical analysis, antimicrobi…
Article
Phytochemical Profile and Antioxidant, Enzyme-Inhibitory, and Cytotoxic Potential of Endemic Cynoglottis chetikiana subsp. chetikiana
Merve Yüzbaşıoğlu Baran, Seren Gündoğdu, András Simon, Hayri Duman, Tuba Reçber, Emirhan Nemutlu, Ayşe Kuruüzüm-Uz
pp. 698–709 · DOI: 10.1177/09731296241277295 · Published 2025
Background: Cynoglottis chetikiana subsp. chetikiana, an endemic Boraginaceae plant growing in Turkey, has not been previously studied in terms of pharmacognosy. However, related species, such as Anchusa, Symphytum, and …
Article
Impact of Berberine Hydrochloride-assisted Metformin on the Metabolism of Glycolipids and Serum Levels of TIMP-1 and TGF-β1 in Individuals with Type 2 Diabetes
Yun Jie, Yongwei Zhang, Weichen Yan
pp. 710–716 · DOI: 10.1177/09731296241287592 · Published 2025
Background: Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and impaired glucose metabolism, leading to hyperglycemia and increased risk of complications like renal fibrosis. Objectives: This study…