Evaluation of the Pogostone in an Acetaminophen-induced Liver Injury Rat Model
Yingkui Hou1, Wencong Sun2, Jing Yang2★★ Corresponding author
- 1Shandong University of Traditional Chinese Medicine, Jinan, CHINA.
- 2Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, CHINA.
CORRESPONDENCE
Jing Yang
Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, CHINA.
Received: 28-08-2024; Accepted: 16-12-2024.
Volume 21, Issue 4 · pp. 1290–1299 · PUBLISHED 2025 · DOI: 10.1177/09731296241311346
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ABSTRACT
Background: One of the leading causes of serious liver disease worldwide is drug-induced liver injury, which is brought on by either the direct hepatotoxic effects of a medication or one of its reactive metabolites. One often-used medication over the counter is acetaminophen (APAP). Although APAP is safe in small amounts, an overdose can result in rapid liver damage and even death from acute liver failure. It is common knowledge that the pharmaceutical business has been using more and more plant products in recent years. Traditional Chinese medicine has utilized patchouli, scientifically known as Pogostemon cablin (P. cablin) Benth, a member of the Lamiaceae family, since the Eastern Han period. Objectives: The current study aims to assess pogostone’s (PO) hepatoprotective effects on rats’ APAP-induced toxicity. Materials and Methods: APAP was used to produce toxicity after two different dosages of PO were given. Liver function markers and biochemical parameters, bilirubin, and protein profile were used to determine the extent of hepatoprotection. The indicators of oxidative stress in the liver and kidney tissue were examined, including superoxide dismutase, catalase, glutathione, and malondialdehyde along with the histopathological analysis. Results: PO has been found to return hepatic and renal antioxidant levels, as well as liver function markers, to normal, compared to the aberrant levels detected in the APAP-treated group. After being observed, it was discovered that the liver weight and liver index were comparable to the positive control. A liver histological examination was also performed, and the results indicated that co-administration with PO significantly reduced the histopathological lesions in the liver caused by APAP. Conclusion: As a result, the current study demonstrates that PO has hepatoprotective effects against liver damage brought on by APAP.
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Hou, Y., Sun, W., & Yang, J. (2025). Evaluation of the Pogostone in an Acetaminophen-induced Liver Injury Rat Model. Pharmacognosy Magazine, 21(4), 1290–1299. https://doi.org/10.1177/09731296241311346