Kaempferol Treatment and Rehabilitation Training Recover the Neurological and Motor Functions in Cerebral Ischemic Injury-induced Rats via MyD88/TLR-4 Pathway

ABSTRACT

Background: Cerebral ischemic stroke, a devastating neurological condition, occurs when the blood supply to a specific region of the brain is interrupted, leading to a cascade of complex physiological and biochemical processes that ultimately result in cellular dysfunction and tissue damage. Objectives: This study was dedicated to assessing the beneficial activities of kaempferol along with rehabilitation training in improving cerebral ischemic stroke-induced neurological complications in the experimental rat model. Materials and Methods: The experimental rats underwent middle cerebral artery occlusion to initiate ischemic stroke. The experimental rats subsequently underwent kaempferol treatment and rehabilitation training alone or in combination. The experimental rats’ neurobehavioral, balance beam, and rotary stick scores were evaluated. The concentrations of inflammation-associated proteins and apoptotic protein levels were assessed in the brain hippocampal tissues of the experimental rats using commercial diagnostic kits. Results: The kaempferol treatment and rehabilitation training alone or in combination significantly decreased the neurobehavioral, balance beam, and rotary stick scores in the rats with ischemic stroke. Furthermore, the kaempferol treatment and rehabilitation training alone or in combination successfully diminished the inflammation-associated protein levels. It regulated the pro- and anti-apoptotic protein concentrations in the brain hippocampal tissues of the rats with cerebral ischemic stroke. Conclusion: The present research highlighted that kaempferol treatment and rehabilitation training alone or in combination can enhance the regaining of neurobehavioral and motor functions in rats with ischemic stroke. The present findings may facilitate the advancement of kaempferol as a new therapeutic candidate to treat ischemic stroke.

KEYWORDS

• Ischemic stroke
• kaempferol
• neuronal apoptosis
• rehabilitation training

Showing references and in-text citations exactly as published.

• DOI10.1177/09731296251321905Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Mag..

• Article · VOLUME 21, ISSUE 4Reserpine Ameliorates 1,2-Dimethylhydrazineinduced Colon Cancer through Regulating Xenobiotic Enzymes and Bax/Caspases/Bcl2-mediated Apoptotic Mechanisms in RatsWenli He, Lina He · pp. 1165–1175Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 4Study on the Neuroprotective Mechanism of Salidroside Modified with Polydopamine Nanoparticles in Regulating Notch Pathway by Inhibiting miR-155 in Stroke Ratsactivity of AQP, TLR TLR, Song Liu, Xiaomeng Lv, Dong Wang · pp. 1176–1186Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 4Exploring Beta-sitosterol’s Role in Breast Cancer Treatment via Integrated Network Pharmacological Analysis and in vitro ValidationJiaxing Yu, Shuqin Cheng, Zelin Ye, Ming Zhang, Xinlei Zhao · pp. 1201–1211Original Research ArticleSame type: Article
• Article · VOLUME 21, ISSUE 4Artemetin Inhibits Cell Growth and Activates Caspase-dependent Apoptotic Cell Death Colon Cancer HCT-116 CellsYan Chen, Lu Men · pp. 1212–1219Original Research ArticleSame type: Article