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    A Comparative Study Between Cheilocostus speciosus (Sea Qust) and Saussurea lappa (Indian Qust): Decoding the Spectral, Anti-bacterial, and Anti-cancer Analyses

    Siddig Ibrahim Abdelwahab1, Manal Mohamed Elhassan Taha1, Syam Mohan1, Mukul Sharma2, Md Shamsher Alam3, Mohamed Eltaib Elmobark3, Sivakumar S Moni1, Mohammed Albeishy4, Ohood Sufyani4, Afraim Koty5, Adel S. Al-Zubairi6★★ Corresponding author

    1. 1Health Research Centre, Jazan University, Jazan, SAUDI ARABIA.
    2. 2Environment and Nature Research Centre, Jazan University, Jazan, SAUDI ARABIA.
    3. 3Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.
    4. 4Forensic Toxicology Services, Forensic Medical Center, Ministry of Health, Jazan, SAUDI ARABIA.
    5. 5Department of Physical Sciences, Chemistry Division, College of Science, Jazan University, Jazan, SAUDI ARABIA.
    6. 6Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, SAUDI ARABIA.
    7. 7Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen.

    CORRESPONDENCE

    Adel S. Al-Zubairi

    Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, SAUDI ARABIA.

    adelalzubairi@hotmail.com

    Received: 04-11-2024; Accepted: 31-01-2025.

    Volume 22, Issue 1 · pp. 125–135 · PUBLISHED 2026 · DOI: 10.1177/09731296251324742

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: This study conducted a comprehensive comparative analysis of Cheilocostus speciosus (sea qust) and Saussurea lappa (Indian qust) using various bioanalytical techniques. Objectives: To identify the undiscovered traits of these two plants C. speciosus (sea qust) and S. lappa (Indian qust). Materials and Methods: Ethanolic extracts were prepared from C. speciosus and S. lappa roots. Chemical composition was determined using gas chromatography–mass spectrometry (GC–MS) and Fourier transform infrared spectroscopy (FTIR). Inductively coupled plasma optical emission spectroscopy (ICP-OES) was utilized to determine the elemental profiles of both extracts. The anti-bacterial and cytotoxic activities were tested against pathogenic microorganisms and MCF-7 cells, respectively. Results: According to GC–MS, each extract contained a distinct collection of compounds, some of which were common to the two plants. While C. speciosus contained xanthosine, S. lappa contained dehydrocostus lactone as the major compound. FTIR analysis confirmed that both extracts contained bioactive functional groups. The two plants have different K, Mn, Cu, Fe, and Zn levels. MCF-7 cells were more responsive to C. speciosus extract, with an IC50 of 122 ± 11.5 μg/mL. The tested bacteria were susceptible to both extracts, with variable responses. Conclusion: Future studies investigating synergistic interactions and creating formulations from extracts of C. speciosus and S. lappa are warranted. This study offers significant insights to therapists, consumers, and researchers regarding the chemicobiological differences between sea and Indian qust.

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      Abdelwahab, S. I., Taha, M. M. E., Mohan, S., Sharma, M., Alam, M. S., Elmobark, M. E., Moni, S. S., Albeishy, M., Sufyani, O., Koty, A., & Al-Zubairi, A. S. (2026). A Comparative Study Between Cheilocostus speciosus (Sea Qust) and Saussurea lappa (Indian Qust): Decoding the Spectral, Anti-bacterial, and Anti-cancer Analyses. Pharmacognosy Magazine, 22(1), 125–135. https://doi.org/10.1177/09731296251324742