Volume 22, Issue 1

Leonurine Attenuates Neuroinflammation and Oxidative Stress in a Pentylenetetrazoleinduced Epilepsy in Rats

Huan Hui, Fan Li

pp. 113–124 · DOI: 10.1177/09731296251322829 · Published 2026

Background: Epilepsy is a complex neurological condition characterized by recurrent seizures due to abnormal neuronal activity. Objectives: The major aim of this study is to examine the therapeutic activities of leonurin…

A Comparative Study Between Cheilocostus speciosus (Sea Qust) and Saussurea lappa (Indian Qust): Decoding the Spectral, Anti-bacterial, and Anti-cancer Analyses

Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Syam Mohan, Mukul Sharma, Md Shamsher Alam, Mohamed Eltaib Elmobark, Sivakumar S Moni, Mohammed Albeishy, Ohood Sufyani, Afraim Koty, Adel S. Al-Zubairi

pp. 125–135 · DOI: 10.1177/09731296251324742 · Published 2026

Background: This study conducted a comprehensive comparative analysis of Cheilocostus speciosus (sea qust) and Saussurea lappa (Indian qust) using various bioanalytical techniques. Objectives: To identify the undiscovere…

Integrate Molecular Docking and Animal Model Validation into the Research of the Effect and Potential Mechanism of Eupatilin Against Myocardial Ischemia/Reperfusion Injury

Yulong Li, Xiang Li

pp. 136–146 · DOI: 10.1177/09731296251323316 · Published 2026

Background: Myocardial ischemia/reperfusion (I/R) injury refers to myocardial tissue damage caused by blood reperfusion after acute heart ischemia caused by coronary artery thrombosis and others. This process is closely …

Albiflorin Enhances Diabetic Wound Healing Process by Enhancing Re-epithelialization and Ameliorating Inflammation and Oxidative Stress in Diabetic Rats

Jie Yang, Xinrong Zhang, Jiawei Zhang, Lu Yan

pp. 147–157 · DOI: 10.1177/09731296251342290 · Published 2026

Background: Diabetes mellitus, a persistent metabolic disorder defined by elevated blood glucose, poses a global public health challenge. One of the most debilitating complications of this disease is the progression of c…

An Investigation of the Protective Effects of Trifolirhizin against MPTP-induced Parkinson’s Disease in Mice

Xiaoli Yuan

pp. 158–166 · DOI: 10.1177/09731296251362609 · Published 2026

Background: Parkinson’s disease (PD) is a prevalent age-associated neurodegenerative disorder, primarily characterized by dopaminergic neuronal loss, oxidative stress, and microglia-mediated neuroinflammation. Current th…

Licoricidin Ameliorates Renal Function via Controlling Stress and Inflammation in Experimental Diabetic Nephropathy Animal Model

Yang Li, Yan Zhao, Rou Shi, Yan Li, Yun-Yun Chen, Zhu Zhou, Hui-Fang Li

pp. 167–177 · DOI: 10.1177/09731296251361610 · Published 2026

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and its currently the leading cause of end-stage renal disease worldwide. Reducing its incidence and delaying its progression are u…

Anti-osteoarthritic Effect of High Bioavailable Curcumin Formulation by Balancing Cartilage Synthesis and Cartilage Degradation in MIA-induced Osteoarthritis Rats

Nehru Sai Suresh Chalichem, Min-Jung Kim, Tae-Jong Kim, Seung-Un Kim, Prasanna Raja, Mohammed S. Khan

pp. 178–193 · DOI: 10.1177/09731296251326792 · Published 2026

Background: Osteoarthritis affects millions of people worldwide. Currently, available pharmacological treatment is limited to topical and oral non-steroidal anti-inflammatory drugs (NSAIDs). Several studies have reported…

Biological Activity and Cell Cycle Effects of Natural Extract Kaempferol on Androgendependent Prostate Cancer Cells

Meikang Peng, Tao Chen, Hongliang Peng

pp. 194–202 · DOI: 10.1177/09731296251325350 · Published 2026

Background: There is an abnormal enhancement of androgen receptor activity in prostate cancer cells, leading to increased sensitivity to androgens and the promotion of cancer cell proliferation. Objectives: This study ai…

Mechanistic of Mulberry Apricot Coughing Granules in Regulating Dysregulated Fluid Metabolism and Inhibiting Ferroptosis in Cough Variant Asthma

Jianjiang Luo, Lixia Wang, Yongwei Zhao, Huifang Liu, Dan Xu, Fengsen Li

pp. 203–216 · DOI: 10.1177/09731296251325347 · Published 2026

Background: Cough variant asthma (CVA) is a distinct type of asthma manifested as dysregulation of fluid metabolism and modulation of ferroptosis. Objectives: The aim of this study was to demonstrate the regulatory effec…

Dezocine Suppresses Myocardial Cell Apoptosis in Rats with Myocardial Ischemia-Reperfusion Injury via TLR4/NF-κB Signaling Pathway

Mingyan He, Ru Liu, Yalin Li, Qi Zhang

pp. 217–222 · DOI: 10.1177/09731296251325341 · Published 2026

Background: Myocardial ischemia-reperfusion (MI/R) injury is a leading cause of myocardial damage, characterized by apoptosis and impaired cardiac function. Dezocine, a mixed opioid receptor agonist/antagonist, has shown…

Ferulic Acid Alleviates Mycoplasma pneumoniaeinduced Pneumonia in Mice by Regulation of Inflammation and ERK/JNK/NF-κB Pathway

Ping Ren, Rongjuan Xi

pp. 223–234 · DOI: 10.1177/09731296251330715 · Published 2026

Background: Pneumonia is a serious respiratory illness that impacts the lungs, leading to inflammation and fluid accumulation in the alveoli, the tiny air sacs essential for gas exchange. Mycoplasma pneumonia is a severe…

Mechanistic Insights into the Immunomodulatory Effects of Velvet Antler Peptides from Sika Deer

Lan-Yue Yin, Jiating Li, Xue-Yue Tai, Guo-Qi Zhang, Ming-Ran Luan, Wu-Yang Hua, Chao Liu, Bao Zhong, Feng-Lin Li

pp. 235–242 · DOI: 10.1177/09731296251329997 · Published 2026

Background: Sika deer antler is a traditional Chinese medicine, and its mechanism of action on immune regulation is still unclear. Therefore, this study aims to explore its related mechanism. Objectives: To investigate t…

Comparative Neuropharmacological Evaluation of Two Herbs (Rosemary and Basil) with Culinary, Medicinal, and Cultural Significance

Sulaiman Mohammed Alnasser

pp. 243–252 · DOI: 10.1177/09731296251331672 · Published 2026

Background: Rosemary (Rosmarinus officinalis) is a perennial herb, while basil (Ocimum basilicum) is an annual herb. Both are utilized in culinary practices and have antioxidant as well as anti-inflammatory properties. H…

Sophocarpine Alleviates Inflammationinduced Colonic Epithelial Barrier Dysfunction in Ulcerative Colitis

Yanmin Zhang, Tianzhi Liu, Zhigang Zuo

pp. 253–264 · DOI: 10.1177/09731296251333262 · Published 2026

Background: Sophocarpine, a quinoline alkaloid derived from Sophora alopecuroides L., is known for its anti-inflammatory effects. These effects are achieved by modulating both nuclear factor-κB (NF-κB) pathway and node-l…

Mechanism of Action of Raspberry Natural Extract on Apoptosis in Human Brain Artery Aneurysm Vascular Endothelial Cells

Junti Lu, Yanhui Zhou, Zhenyu Xia, Bowen Yang, Gao Wu, Hui Gui, Shiwen Guo

pp. 265–276 · DOI: 10.1177/09731296251321210 · Published 2026

Background and Objectives: Raspberry natural extract exhibits a regulatory effect on apoptosis in human brain artery aneurysm vascular endothelial cells (VECs). This work was to gain deeper insights into the impact of ra…

Mechanism of Ginkgo Diterpene Lactone Meglumine Injection Promoting Angiogenesis and Improving Cerebral Perfusion in Cerebral Infarction Rats

Tao Zhan, Ruixia Li, Jiahui Shen, Xinya Chen, Pingguo Liu

pp. 277–288 · DOI: 10.1177/09731296251313639 · Published 2026

Background: In recent years, traditional Chinese medicine has shown advantages in treating ischemic cerebrovascular diseases, including multi-component, multi-target, and low toxicity effects. Objectives: The aim of this…

α-Mangostin Shows Chemopreventive Activity in Benzo[a]pyrene-induced Lung Cancer in Mice Via Regulation of Apoptosis and Tumor Biomarkers

Yuan Feng, Jinxiu Guo, Chao Wang, Zonglin Shi

pp. 289–299 · DOI: 10.1177/09731296251341499 · Published 2026

Background: Lung cancer is a serious disease affecting millions of individuals globally, defined by the unregulated proliferation of abnormal cells in the lungs. It is the primary cause of cancer-associated fatalities wo…

Fisetin Attenuates Experimental Periodontal Disease in Rats via Regulating BMP-2/TIMP-1 and OPG/RANKL Signaling Pathways

Lu Li, Xuxi Chen, Yufei Xue, Weiyi Chen

pp. 30–42 · DOI: 10.1177/09731296251324704 · Published 2026

Background: Periodontitis is a persistent inflammatory condition that mainly affects the supportive tissues of the teeth, comprising the gingiva, periodontal ligament, and alveolar bone. Objectives: The present study foc…

Vicenin-2 Exerts Bidirectional Immunomodulation via p38MAPK Phosphorylation in RAW264.7 Macrophages

Xi Duan, Shuang Du, Hao Yang, Jia He, Lei Zhang, Yunzhu Mu

pp. 300–310 · DOI: 10.1177/09731296251360569 · Published 2026

Background: Inflammatory diseases, including autoimmune disorders, and chronic inflammatory conditions, are driven by dysregulated immune responses, particularly involving macrophage activation. Macrophages play a critic…

The Purified Fraction of Persicaria capitata Flowers Attenuates Proliferation in A-431 Cell Lines

Vikrant Arya, Amandeep Kaur Gill, Yatendra Singh, Ashutosh Acharya, Anupam Jamwal

pp. 311–320 · DOI: 10.1177/09731296251333884 · Published 2026

Background: Squamous cell carcinoma is a skin carcinoma and can be fatal if not cured on time. Overexposure to ultraviolet (UV) light is the most common causative agent responsible for such a condition. Genetic and immun…

Sinensetin Shows Neuroprotective Effects in Aluminum Chloride-induced Alzheimer’s Disease in Rats by Regulating BDNF/PPAR-γ/p38MAPK/NF-κB Pathways

Fuhua Gong, Yujia Su, Tao Wu, Tahani Awad Alahmadi, Hesham S. Almoallim

pp. 321–333 · DOI: 10.1177/09731296251379601 · Published 2026

Background: Alzheimer’s disease (AD) is a neurological disorder characterized by behavioral and memory deficits, along with cognitive impairments. The majority of AD cases are often present in individuals aged 60 and abo…

Sophoricoside Inhibits Cell Growth and Induces Oxidative Stress-dependent Apoptosis in Colon Cancer HCT-116 Cells

Zheng Zhang, Qian Zheng, Dongli Zhang, Shaowen Li

pp. 334–341 · DOI: 10.1177/09731296251361618 · Published 2026

Background: Colorectal cancer constitutes a major global health issue, defined by the unregulated growth of atypical cells in the large intestine or rectum. This intricate disease, resulting from a combination of genetic…

Forsythia suspensa Ethanolic Extract Alleviates Mycoplasma pneumoniae-induced Lung Inflammation via Inhibition of NF-κB Signaling

Yuhang Xue, Ji Hui, Juan Li, Xia Li, Jifeng Tian, Yanping Shi

pp. 342–353 · DOI: 10.1177/09731296251346353 · Published 2026

Background/Objectives: Mycoplasma pneumoniae is a significant contributor to respiratory tract infections, notably community-acquired pneumonia (CAP), bronchitis, and exacerbations of chronic lung diseases. Its epidemiol…

Diosmetin Enhances Apoptosis in Thyroid Cancer CAL-62 Cells via Increasing Oxidative Stress and Inhibiting PI3K/AKT/mTOR Pathway

Zhibin Jiang, Dandan Liu, Jia Lv, Xiaoli Chen, Xiaoxu Zhou, Qian Sun, Hongli Yang

pp. 354–362 · DOI: 10.1177/09731296251348747 · Published 2026

Background: Thyroid cancer is a malignancy that arises from the thyroid gland. While it is considered an uncommon condition, cases of thyroid cancer have been steadily rising in recent years worldwide. Objectives: The pr…

Scopoletin Induces Apoptosis in Ovarian Cancer A2780 Cells via Regulating Caspases and Bax/Bcl-2 Pathway

Fang Wang, Limin Chen, Jie Cui, Shasha Bai

pp. 363–372 · DOI: 10.1177/09731296251348751 · Published 2026

Background: Ovarian cancer is a devastating disease that affects the female reproductive system, specifically the ovaries, which are responsible for producing eggs and the female reproductive hormones. Despite improvemen…

Tribulosin Alleviates Ovariectomy-induced Osteoporosis by Inhibiting the RANKL Pathway and Inflammatory Responses

Haifei Zhang, Kai Li

pp. 373–384 · DOI: 10.1177/09731296251360086 · Published 2026

Background/Objectives: Osteoporosis is a prevalent metabolic bone disorder characterized by a progressive loss of bone density and structural deterioration, significantly affecting the geriatric population, particularly …

Xanthohumol Activates Pro-apoptotic Mechanisms in Renal Cancer A498 Cells by Increasing Apoptotic Proteins and Inhibiting PI3K/AKT/mTOR Pathway

Zhongkang Lai, Ziyan Wang

pp. 385–394 · DOI: 10.1177/09731296251351701 · Published 2026

Background: Kidney cancer, also called renal cancer, is a kind of malignancy that develops in the kidneys. Kidney cancer is a major health issue that has garnered increasing attention in the medical community due to its …

Sesquiterpene Curzerenone Activates Apoptotic Signaling and Attenuates PI3K/AKT/mTOR Signaling in HepG2 Cells by Triggering Oxidative Stress

Yujian Tian, Zhongjie Cao, Renshuan Li

pp. 395–406 · DOI: 10.1177/09731296251348104 · Published 2026

Background/Objectives: Curzerenone is a sesquiterpene primarily isolated from Curcuma zedoaria rhizomes, identified for its diverse therapeutic efficacy. Recent studies have highlighted curzerenone’s potential anti-cance…

Curcumin Regulates Lipid Mobilization Factors Through S100A9 in Patients With Anorexia– Cachexia Syndrome in Head and Neck Cancer

Shujing Qi, Gaixia Fu, Zhaozhen Chu

pp. 43–52 · DOI: 10.1177/09731296251330001 · Published 2026

Background: Anorexia–cachexia syndrome in head and neck cancer (ACSHNC) seriously affects the patient’s quality of life and prognosis. Curcumin inhibits head and neck cancer and anorexic cachexia syndrome. S100A9 is rela…

Deciphering the Intricacies of Breast Cancer Signaling Network and the Potential of Soy-derived Isoflavones on Cancer Therapeutics

Amir Mahgoub Awadelkareem, Abd Elmoneim O. Elkhalifa, Mohd Adnan, Mohammed Kuddus, Mohammed Idreesh Khan, Manojkumar Sachidanandan, Fauzia Ashfaq, Mirza Sarwar Baig, Syed Amir Ashraf

pp. 53–66 · DOI: 10.1177/09731296251322233 · Published 2026

Background: Breast cancer remains a significant global health challenge despite the emergence of various drug molecules. However, the adverse side effects of several drugs and chemotherapy necessitate the exploration of …

Mechanism of Alginate-Collagen Hydrogel in the Repair of Rat Cartilage Injury

Yezhou Li, Chengjian Tang

pp. 67–79 · DOI: 10.1177/09731296251323311 · Published 2026

Background and Objectives: Alginate and gelatin have biocompatibility and biodegradability for drug formulations or carriers, but the roles and mechanisms in cartilage injury (CI) repair remain unclear. This research inv…

Therapeutic Effects of Dendrobium Extract on Pathologic Lens Alterations in Diabetic Cataract Patients

Baoping Duan, Hongyan Ge, Meng Sun, Sheng Su, Shiqiang Zhao, Ping Liu

pp. 80–89 · DOI: 10.1177/09731296251325353 · Published 2026

Background: Diabetic cataract, an ocular complication arising from diabetes, can lead to damage to ocular tissues, particularly affecting the lens and causing symptoms such as blurred vision. Objectives: This work aimed …

Allicin Combined with Cisplatin Inhibits the Growth and Metastasis of Lewis Cells in Lung Cancer Mice

Bin Zhang, Xinghui Ren, Juan Wang, Wei Zhang

pp. 90–98 · DOI: 10.1177/09731296251325329 · Published 2026

Background: Allicin has anti-tumor activity and an inhibitory effect on lung cancer. Objectives: In this experiment, lung cancer mice were used as the research subjects to explore the mechanism of allicin with cisplatin …

Immunomodulatory and Anti-cancer Potency of Lysergol on Benzo[a]pyrene-induced Lung Carcinogenesis and Attenuation of Tumor Progression in Mice Model

Yaming Li, Jiayin Liu, Shuang Pan

pp. 99–112 · DOI: 10.1177/09731296251324741 · Published 2026

Background: Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon exposure, is a major public health issue globally, particularly as a result of its connection to lung cancer. Individuals exposed to higher levels of …

Therapeutic Potential of Flavonoids in Osteosarcoma: Molecular Mechanisms and Clinical Implications

Zhenhai Cai, Jieen Pan, Xiaojun He, Wenmin Wang, Zhengwei Zhou

pp. 17–29 · DOI: 10.1177/09731296241305887 · Published 2026

Osteosarcoma (OS) is a predominant malignancy among children and adolescents, ranked third in frequency after lymphoma and leukemia. It presents a significant risk of metastasis, particularly to the lungs and distal bone…

Current Review on Ethnopharmacological Approach on Medicinal Value of Cordia macleodii as a Traditional Herb of Importance

Khemkaran Ahirwar, Junaid Khan, Anand Kumar, Mukesh Nag

pp. 7–16 · DOI: 10.1177/09731296251330393 · Published 2026

Background: The medicinal properties of plants and plant derivatives have led to their long-term use in medicine. Objectives: The present review article was drafted to discuss the traditional importance of Cordia macleod…

Retraction Notice: Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line

pp. 407–407 · DOI: 10.4103/0970-1591.117278 · Published 2026