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    Therapeutic Potential of Flavonoids in Osteosarcoma: Molecular Mechanisms and Clinical Implications

    Zhenhai Cai1, Jieen Pan1, Xiaojun He1, Wenmin Wang2, Zhengwei Zhou1★★ Corresponding author

    1. 1Department of Orthopedics Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, CHINA.
    2. 2The Yangtze River Delta Biological Medicine Research and Development Center of Zhejiang Province, Yangtze Delta Region Institution of Tsinghua University, Jiaxing, Zhejiang, CHINA.

    CORRESPONDENCE

    Zhengwei Zhou

    Department of Orthopedics Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, CHINA.

    xiaomo0213@163.com

    Received: 25-09-2024; Accepted: 06-11-2024.

    Volume 22, Issue 1 · pp. 17–29 · PUBLISHED 2026 · DOI: 10.1177/09731296241305887

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Osteosarcoma (OS) is a predominant malignancy among children and adolescents, ranked third in frequency after lymphoma and leukemia. It presents a significant risk of metastasis, particularly to the lungs and distal bones, leading to severe disease progression and increased mortality. Current treatment modalities, primarily surgery and chemotherapy, are associated with considerable side effects and variable prognoses, underscoring the urgent need for novel, more effective, and less harmful therapeutic options. Flavonoids, naturally occurring polyphenolic compounds, have shown promising potential in the management of OS. This article evaluates the molecular mechanisms through which flavonoids exert therapeutic effects on OS and explores their potential in developing innovative treatments. The review provides insights into their roles in inducing apoptosis, inhibiting cell proliferation, and modulating key signaling pathways in OS cells by examining the anticancer properties of specific flavonoids such as apigenin, quercetin, and baicalein. The comprehensive analysis aims to contribute to advancing flavonoid-based therapies, opening new avenues for practical and safer OS treatments.

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      Cai, Z., Pan, J., He, X., Wang, W., & Zhou, Z. (2026). Therapeutic Potential of Flavonoids in Osteosarcoma: Molecular Mechanisms and Clinical Implications. Pharmacognosy Magazine, 22(1), 17–29. https://doi.org/10.1177/09731296241305887