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    Global yield of the Supercritical CO2 extraction from Cordia verbenacea DC - Anticancer and antimycobacterial activities

    Sócrates Quispe-Condori1, Paulo T. V. Rosa1, Daisy N. Sato2, João E. Carvalho3, Mary A. Foglio3, M. Angela A. Meireles1★★ Corresponding author

    1. 1LASEFI–DEA/ FEA (College of Food Engineering) – UNICAMP (State University of Campinas), Caixa Postal 6121, 13083-970 Campinas, São Paulo, Brazil.
    2. 2Instituto Adolfo Lutz, Laboratório de Ribeirão Preto, Rua Minas 877, 14085-410, Campos Elíseos, Ribeirão Preto, São Paulo, Brazil.
    3. 3CPQBA / UNICAMP – Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas da Unicamp, Estrada PLN 393, 999 Vila Betel, Caixa Postal 6171, 13081-970 Paulínia, São Paulo, Brazil.

    CORRESPONDENCE

    M. Angela A. Meireles

    LASEFI–DEA/ FEA (College of Food Engineering) – UNICAMP (State University of Campinas), Caixa Postal 6121, 13083-970 Campinas, São Paulo, Brazil.

    meireles@fea.unicamp.br

    Volume 3, Issue 9 · pp. 39–40 · PUBLISHED 2007 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    In the present work supercritical fluid extraction (SFE) from Cordia verbenacea DC was studied. The effects of pressure and temperature on the global yield were investigated using the Surface Response Methodology. Extracts of C. verbenacea were also prepared by hydrodistillation and Soxhlet using ethanol. The chemical compositions of the extracts were determined by GC-FID. The anticancer and antimycobacterial activities of the extracts were evaluated. The results show that pressure and temperature significantly affected the global yield (pvalue < 0.05). The maximum global yield was obtained at 300 bar and 50°C (4.25 % dry basis – d.b.). The extract obtained by Soxhlet using ethanol showed the highest yield (8.13 ± 0.01 % d.b). β-caryophyllene was identified as the major compound in the volatile fraction. The anticancer activity of the SFE extracts varied with the operational condition. The SFE extract obtained at 200 bar and 40 °C showed the best results and it is similar to that presented by the extracts obtained by hydrodistillation and Soxhlet extraction. The SFE extracts showed a lower antimycobacterial activity.

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      Quispe-Condori, S., Rosa, P. T. V., Sato, D. N., Carvalho, J. E., Foglio, M. A., & Meireles, M. A. A. (2007). Global yield of the Supercritical CO2 extraction from Cordia verbenacea DC - Anticancer and antimycobacterial activities. Pharmacognosy Magazine, 3(9), 39–40.