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    Antinociceptive and anti-inflammatory effects of Cleome chelidonni Linn. roots in experimental animals

    Goverdhan Puchchakayala1★, Laxmi Podili2, Diwakar Bobbala3, Thirupathi K4, Krishna M. Boini4, Narasimha Reddy Yellu4, Ravi Kumar Bobbala4, Krishna Mohan Gottemukkala4, Rajeshwara Rao Pragada4★ Corresponding author

    1. 1University College of pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India-506 009, India.
    2. 2Vaagdevi College of Pharmacy, Warangal, Andhrapradesh, India-506 009, India.
    3. 3Department of Physiology, University of Tüebingen, Tübingen, Germany.
    4. 4College of Pharmacy, Andhra University, Visakhapatnam-530 003, India.

    CORRESPONDENCE

    Goverdhan Puchchakayala

    University College of pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India-506 009, India.

    reddy_pharmacology@yahoo.com

    Volume 4, Issue 13 · pp. 32–33 · PUBLISHED 2008 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The effect of Cleome chelidonni Linn (Family: Capparidaceae) methanolic methanolic root extract was studied for the antinociceptive and anti-inflammatory activity in experimental animals. C. chelidonni, 25 – 100 mg/kg administered orally for 3 days exhibited graded dose response equivalent to 21.95% - 89.90% protection in the tail flick latent test in rat. The C. chelidonni methanolic root extract (50 and 100 mg/kg, p.o X 3 days) was effective in hot plate reaction time (64.05% and 112.97%, p< 0.01 and p< 0.001), analgesymeter induced mechanical pain (28.17% and 54.42%, p < 0.01 and p < 0.001) and acetic acid- induced writhing (26.68% and 51.79%, p < 0.5 and p < 0.05) in mice. The methanolic root extract of C. chelidonni potentiated the analgesic activity with pentazocine (10 mg/kg, i.p.) and aspirin (25 mg/kg, i.p.). In the carrageenan- induced paw edema C. chelidonni methanolic root extract (50 and 100 mg/kg, p.o X 3 days) decreased paw volume significantly (26.68% and 51.79%) and dose dependent anti-inflammatory activity in 1-3 hour time interval and potentiated with nimesulide (50 mg/kg, p.o.). In summary, this study demonstrates that methanolic methanolic root extract of C. chelidonni has significant antinociceptive and anti-inflammatory activity.

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      Puchchakayala, G., Podili, L., Bobbala, D., K, T., Boini, K. M., Yellu, N. R., Bobbala, R. K., Gottemukkala, K. M., & Pragada, R. R. (2008). Antinociceptive and anti-inflammatory effects of Cleome chelidonni Linn. roots in experimental animals. Pharmacognosy Magazine, 4(13), 32–33.