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    Chemical Composition and Hepato-protective activity of Imperata cylindrica Beauv.

    Gamal A. Mohamed1, Ahmed Abdel-Lateff2, Mostafa A. Fouad3, Sabrin R. M. Ibrahim4, Ehab S. Elkhayat4★, Tatsufumi Okino4★ Corresponding author

    1. 1Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
    2. 2Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
    3. 3Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
    4. 4Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan.

    CORRESPONDENCE

    Ehab S. Elkhayat

    Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan.

    khayat71@yahoo.com

    Received: 10-05-2008; Revised: 07-07-2008; Accepted: 02-08-2008.

    Volume 5, Issue 17 · pp. 28–36 · PUBLISHED 2009 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Phytochemical study of the aerial parts of Imperata cylindrica Beauv. (Graminae), growing in Egypt afforded four methoxylated flavonoids 1-4, β-sitosterol-3-O-β-D-glucopyranosyl-6´-tetradecanoate 5, 3-hydroxy-4-methoxy-benzaldehyde 6, together with daucosterol, β-sitosterol and α-amyrin 7-9. To the best of our knowledge, this is the first isolation of compounds 1-5 from the genus Imperata. A significant hepato-protective activity had been observed upon co-administration of the methanolic extracts of I. cylindrica with CCl4. The structures were determined using spectroscopic data; 1D (1H and 13C), 2D (HSQC, and HMBC) NMR; MS; UV and IR.

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      Mohamed, G. A., Abdel-Lateff, A., Fouad, M. A., Ibrahim, S. R. M., Elkhayat, E. S., & Okino, T. (2009). Chemical Composition and Hepato-protective activity of Imperata cylindrica Beauv.. Pharmacognosy Magazine, 5(17), 28–36.