Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Anti-inflammatory and wound healing potential of Prosthechea michuacana in rats

    Rosa Martha Perez Gutierrez1★, Rosario Vargas Solis2★ Corresponding author

    1. 1Laboratorio de Investigación de Productos Naturales. Escuela Superior de Ingeniería Química e Industrias extractivas IPN. Punto Fijo 16, Col. Torres Lindavista, cp 07708. Mexico D.F, Mexico.
    2. 2Laboratorio de Investigación de Fitofarmacología. Universidad Autónoma Metropolitana-ochimilco A.P. 23-181 Mexico D.F, Mexico.

    CORRESPONDENCE

    Rosa Martha Perez Gutierrez

    Perez Gutierrez Rosa Martha,Laboratorio de Investigación de Productos Naturales. Escuela Superior de Ingeniería Química e Industrias extractivas IPN. Punto Fijo 16, Col. Torres Lindavista, cp 07708. Mexico D.F, Mexico.

    rmpg@prodigy.net.mx

    Received: 05-03-2009; Accepted: 20-05-2009.

    Volume 5, Issue 19 · pp. 219–225 · PUBLISHED 2009 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The hexane, methanol and chloroform extracts of bulbs of orchid Prosthechea michuacana (PMIC) were studied for their wound healing and anti-inflammatory properties. Wound healing effects were studied on incision (skin breaking strength), excision (percent wound contraction). Collagen, hexosamine, total protein and DNA content in the granulation tissues were determined in addition to the rates of wound contraction and period of epithelialization. Topical applications of hexane extract PMIC produced increases in tensile strength, collagen content (hydroxyproline), and is better epithelisation thereby facilitating the healing. The hexane extract also was found possess significant anti-inflammatory activity in both acute (carrageenin-induced edema) as well as subacute (cotton pellet) animals models. Thus it could concluded that PMIC hexane may enhance the process of wound healing by influencing phases such as inflammation, fibroplasias, collagen synthesis and maturation, and wound contraction. Hexane extract significantly inhibited later phase of edema so it seems possible that P. michuacana blocks prostaglandins and cyclooxygenase release in later phase of acute inflammation, consequently decrease in granuloma weight indicates the suppression of the proliferative phase, which was effectively inhibited by the PMIC.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Gutierrez, R. M. P., & Solis, R. V. (2009). Anti-inflammatory and wound healing potential of Prosthechea michuacana in rats. Pharmacognosy Magazine, 5(19), 219–225.