Gastric ulcer healing activity of Sri Lankan black tea (Camellia sinensis L.) in rats
WD Ratnasooriya1★, TSP Fernando1★ Corresponding author
- 1Department of Zoology, University of Colombo, Colombo 03, Sri Lanka.
CORRESPONDENCE
WD Ratnasooriya
Ratnasooriya WD,Department of Zoology, University of Colombo, Colombo 03, Sri Lanka.
Received: 27-03-2009; Revised: 01-04-2009; Accepted: 22-04-2009.
Volume 5, Issue 19 · pp. 260–265 · PUBLISHED 2009 · DOI:
View on Pharmacogn. Mag. original site ↗
ABSTRACT
This study examined the gastric ulcer healing potential of black tea (Camellia sinensis) using Sri Lankan high grown Dust grade No: 1 black tea in rat acetic acid-induced gastric ulcer model. Three oral doses (84, 167 or 501 mg/ml) of black tea brew (BTB) made according to ISO recommendations were used in the evaluation of gastric ulcer healing activity. The results showed a significant (P < 0.05) and dose-dependent gastric ulcer healing activity (in terms of reduction in gastric ulcer area). This effect had a rapid onset (with in 14 days). The gastric ulcer healing activity of BTB was however inferior (by 9 fold) to omeparazole, the reference drug. BTB displayed in vitro antioxidant activity (using DPPH assay; by 2985–3923 Trolox equivalents μg/l), and also inhibited in vitro nitric oxide production (3–78 %). In addition, BTB had antihistamine activity (by wheal test; by 33.5%) and increased the gastric pH (from 3.3 to 5.9) and impaired the gastric acid output (by 69%). It is concluded that black tea possessed strong, oral gastric ulcer healing activity which is mediated via multiple mechanisms.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Ratnasooriya, W., & Fernando, T. (2009). Gastric ulcer healing activity of Sri Lankan black tea (Camellia sinensis L.) in rats. Pharmacognosy Magazine, 5(19), 260–265.