Synergistic effect of Withania somnifera Dunal and L-dopa in the inhiition of haloperidol-induced catalepsy in mice
Lal Gupta Girdhari1, Chand Rana Avtar1★★ Corresponding author
- 1Department of Pharmacology, B. N. College of Pharmacy, Udaipur-313 002 (Rajasthan) India, India.
CORRESPONDENCE
Chand Rana Avtar
Department of Pharmacology, B. N. College of Pharmacy, Udaipur-313 002 (Rajasthan) India, India.
Received: 10-10-2008; Accepted: 06-06-2009.
Volume 5, Issue 19s · pp. 46–50 · PUBLISHED 2009 · DOI:
View on Pharmacogn. Mag. original site ↗
ABSTRACT
The possible synergism between WS and dopamine precursor L-dopa to inhibit haloperidol-induced catalepsy was investigated by using standard bar test in mice. The effect of WS (20–200 mg/kg, oral), L-dopa (20–200 mg/kg, oral) plus carbidopa and combination of subeffective doses of WS (20 or 50 mg/kg, oral) prior to L-dopa (20, 50 or 100 mg/kg, oral) plus carbidopa was assessed in haloperidol (1 mg/kg, i.p.) induced catalepsy. L-dopa and carbidopa combination was always administered in 10:1 ratio. WS (100 or 200 mg/kg, oral) and L-dopa (50, 100 or 200 mg/kg, oral) plus carbidopa treated groups showed a dose dependent reduction in cataleptic scores. Subeffective doses of WS (20 or 50 mg/kg, oral) prior to L-dopa (20, 50 or 100 mg/kg, oral) also potentiated the anticataleptic effect of L-dopa. These results indicate that subeffective doses of WS enhance the anticataleptic actions of L-dopa and the possibility of using WS as adjunctive therapy to reduce the doses and the adverse effects of dopamine precursor in Parkinson’s disease.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Girdhari, L. G., & Avtar, C. R. (2009). Synergistic effect of Withania somnifera Dunal and L-dopa in the inhiition of haloperidol-induced catalepsy in mice. Pharmacognosy Magazine, 5(19s), 46–50.