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    Phytochemical Study and Evaluation of Antioxidant, Neuroprotective and Acetylcholinesterase Inhibitor Activities of Galeopsis ladanum L. extracts

    Uriarte Pueyo1★, MI Calvo1★ Corresponding author

    1. 1Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, 31008 Pamplona (Navarra), Spain.

    CORRESPONDENCE

    Uriarte Pueyo

    I,Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, 31008 Pamplona (Navarra), Spain.

    iuripue@yahoo.com

    Received: 02-04-2009; Accepted: 04-06-2009.

    Volume 5, Issue 20 · pp. 287–290 · PUBLISHED 2009 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The antioxidant activity, neuroprotective effect and acetylcholinesterase activity of the dichloromethane, ethyl acetate, methanol and water extracts of seeds, leaves and roots of Galeopsis ladanum L. were investigated. Ethyl acetate, methanol and water extracts of leaves showed the highest antioxidant activity (DPPH). Methanol and water extracts of seeds and the water extract of roots showed neuroprotective effect on hydrogen peroxide induced apoptosis in rat pheochromocytoma PC12 cells. Some dichloromethane, ethyl acetate and water extracts exhibited antiacetylcholinesterase activity by TLC.

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      Pueyo, U., & Calvo, M. (2009). Phytochemical Study and Evaluation of Antioxidant, Neuroprotective and Acetylcholinesterase Inhibitor Activities of Galeopsis ladanum L. extracts. Pharmacognosy Magazine, 5(20), 287–290.