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    Article

    Hypolipidemic Effects of Seed Extract of Celery (Apium graveolens) in Rats

    Mansi Kamal1, Abushoffa Adel M2, Disi Ahmad3, Aburjai Talal4★★ Corresponding author

    1. 1Department of Biological Sciences, Faculty of Science, Al al-bayt University, Mafraq-Jordan, Jordan.
    2. 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alfateh University of Medical Sciences, Tripoli, P.O.Box 13620, Libya.
    3. 3Department of Biological Sciences, Faculty of Science, University of Jordan, Amman 11942 Jordan, Jordan.
    4. 4Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942 Jordan, Jordan.

    CORRESPONDENCE

    Aburjai Talal

    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942 Jordan, Jordan.

    aburjai@ju.edu.jo

    Received: 02-04-2009; Revised: 14-04-2009; Accepted: 08-06-2009.

    Volume 5, Issue 20 · pp. 301–305 · PUBLISHED 2009 · DOI:

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The hypolipidemic effects of ethanol extract of A. graveolens L. (Apiaceae) were investigated. Forty adult male albino rats weighing about 260 g each, were divided into four groups (n = 10). Experimental animals were gavaged at doses of 213 and 425 mg/kg body wt. for sixty consecutive days. Extract showed a significant decrease (p<0.05) of serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-c), and significant increase (p<0.05) in high-density lipoprotein cholesterol (HDL-c) in the treated groups. The oral administration of ethanol extract of A. graveolens revealed good hypolipideamic effects in adult male albino rats. The results have given a considerable agreement to the traditional use of A. graveolens in the treatment of hyperlipidemia; it could possibly lead to appropriate changes in blood lipid profiles.

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      Kamal, M., M, A. A., Ahmad, D., & Talal, A. (2009). Hypolipidemic Effects of Seed Extract of Celery (Apium graveolens) in Rats. Pharmacognosy Magazine, 5(20), 301–305.