Cytotoxic and Antibacterial Constituents from the Roots of Sonchus oleraceus L. Growing in Egypt
Elkhayat Ehab Saad1★★ Corresponding author
- 1Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut 71524, Egypt.
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Elkhayat Ehab Saad
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut 71524, Egypt.
Received: 03-05-2009; Revised: 15-05-2009; Accepted: 20-06-2009.
Volume 5, Issue 20 · pp. 324–328 · PUBLISHED 2009 · DOI:
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ABSTRACT
Phytochemical study of the roots of Sonchus oleraceus L. (Astraceae) Growing in Egypt, afforded loliolide 1 for the first time from the genus Sonchus in addition to 15-O- β-glucopyranosyl-11 β,13-dihydrourospermal A 2 , ursolic acid 3 , lupeol 4 and β-sitosterol-3-O-glucopyranoside 5 for the first time from the plant. The biological evaluation of the isolated compounds showed cytotoxic activity of 1 and 2 against PC33 and L5187Y cell lines, in addition to antibacterial activity against S.aureus, B. subtilis, E. Coli and N. gohnorea. The structures of the compounds were elucidated using 1D ( 1 H and 13C), 2D (H-H COSY, H S QC and HMBC) NMR and MS spectroscopic data.
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Saad, E. E. (2009). Cytotoxic and Antibacterial Constituents from the Roots of Sonchus oleraceus L. Growing in Egypt. Pharmacognosy Magazine, 5(20), 324–328.