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    Article

    Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion

    Abdullah Böyük1★, Akın Önder1, Murat Kapan1, Metehan Gümüş1, Uğur Fırat2, Mustafa Kemal Başaralı3, Harun Alp4★ Corresponding author

    1. 1Departments of General Surgery, School, Dicle University, Diyarbakır, Turkey.
    2. 2Pathology and, Turkey.
    3. 3Biochemistry, Medical School, Dicle University, Diyarbakır, Turkey.
    4. 4Department of Pharmacology and Toxicology, Veterinary School, Dicle University, Diyarbakır, Turkey.

    CORRESPONDENCE

    Abdullah Böyük

    Departments of General Surgery, School, Dicle University, Diyarbakır, Turkey.

    Received: 21-01-2011; Revised: 13-02-2011.

    Volume 7, Issue 27 · pp. 224–228 · PUBLISHED 25 August 2011 · DOI: 10.4103/0973-1296.84236

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches. Materials and Methods: Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy. Results: TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group. Conclusion: These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury.

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      Böyük, A., Önder, A., Kapan, M., Gümüş, M., Fırat, U., Başaralı, M. K., & Alp, H. (2011). Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion. Pharmacognosy Magazine, 7(27), 224–228. https://doi.org/10.4103/0973-1296.84236