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    Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells

    Surendra Kumar Sharma1★, Sheela Meruga Arogya1, Deepak Hiraganahalli Bhaskarmurthy2, Amit Agarwal2, Chandrasekaran Chinampudur Velusami2★ Corresponding author

    1. 1Department of Pharmaceutical Sciences, Gurujambeshwar University, Hissar, Haryana, India.
    2. 2R and D Centre, Natural Remedies Pvt. Ltd., Bangalore, Karnataka, India.

    CORRESPONDENCE

    Surendra Kumar Sharma

    Department of Pharmaceutical Sciences, Gurujambeshwar University, Hissar, Haryana, India.

    Received: 20-01-2011; Revised: 22-02-2011.

    Volume 7, Issue 27 · pp. 229–233 · PUBLISHED 25 August 2011 · DOI: 10.4103/0973-1296.84237

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Phyllanthus (Euphorbiaceae) species have long been used in folk medicine to treat various pathological conditions including liver diseases. Some species of Phyllanthus were found to exhibit hepatoprotective activity against drugs or toxins and this property was majorly attributed to phyllanthin and hypophyllanthin. In this study, we examined the hepatoprotective activity of five different species of Phyllanthus, namely, Phyllanthus amarus, Phyllanthus fraternus, Phyllanthus maderaspatensis, Phyllanthus urinaria, and Phyllanthus Rotundifolius. The extracts were also evaluated for the presence of key phytoconstituents, phyllanthin and hypophyllanthin. Materials and Methods: The extracts were evaluated for hepatoprotective activity against tert- butyl hydroxide (t-BH)-induced cytotoxicity using human hepatocarcinoma cells (HepG2 cell line). Results: Only P. urinaria and P. maderaspatensis exhibited significant hepatoprotective activity as evident from increased cell viability. The HPLC profile revealed that except P. amarus, the other extracts did not contain phyllanthin and hypophyllanthin. Conclusion: P. urinaria and P. maderaspatensis demonstrated dose-dependent hepatoprotective activity and hence, can provide promising therapeutic interventions against chemical—induced liver damage.

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      Sharma, S. K., Arogya, S. M., Bhaskarmurthy, D. H., Agarwal, A., & Velusami, C. C. (2011). Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells. Pharmacognosy Magazine, 7(27), 229–233. https://doi.org/10.4103/0973-1296.84237