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    Article

    Antioxidative effects of Cinnamomi cortex: A potential role of iNOS and COX-II

    Jin-Won Chung1, Jeong-Jun Kim1, Sung-Jin Kim1★★ Corresponding author

    1. 1Department of Pharmacology and Toxicology, School of Dentistry, Kyung Hee University, Seoul, Korea 130-701.

    CORRESPONDENCE

    Sung-Jin Kim

    Department of Pharmacology and Toxicology, School of Dentistry, Kyung Hee University, Seoul, Korea 130-701.

    kimsj@khu.ac.kr

    Received: 04-12-2010; Revised: 17-01-2011.

    Volume 7, Issue 28 · pp. 314–319 · PUBLISHED 30 November 2011 · DOI: 10.4103/0973-1296.90412

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Cinnamomi cortex has wide varieties of pharmacological actions such as anti- inflammatory action, anti-platelet aggregation, and improving blood circulation. In this study, we tested to determine whether the Cinnamomi cortex extract has antioxidant activities. Materials and Methods: Antioxidative actions were explored by measuring free radical scavenging activity, NO levels, and reducing power. The mechanism of antioxidative action of Cinnamomi cortex was determined by measuring iNOS and COX-II expression in lipopolysaccharide (LPS) stimulated Raw cells. Results: Seventy percent methanolic extract of Cinnamomi cortex exerted significant 1,1diphenyl-2-picrylhydrazyl (DPPH) free radicals and NO scavenging activities in a dose-dependent manner. More strikingly, the Cinnamomi cortex extract exerted dramatic reducing power activity (13-fold over control). Production of iNOS induced by LPS was significantly inhibited by the Cinnamomi cortex extract, suggesting that it inhibits NO production by suppressing iNOS expression. Additionally, COX-2 induced by LPS was dramatically inhibited by the Cinnamomi cortex extract. Conclusion: These results suggest that 70% methanolic extract of Cinnamomi cortex exerts significant antioxidant activity via inhibiting iNOS and COX-II induction.

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      Chung, J., Kim, J., & Kim, S. (2011). Antioxidative effects of Cinnamomi cortex: A potential role of iNOS and COX-II. Pharmacognosy Magazine, 7(28), 314–319. https://doi.org/10.4103/0973-1296.90412