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    Biodistribution properties of cleistanthin A and cleistanthin B using magnetic resonance imaging in a normal and tumoric animal model

    Subramani Parasuraman1★, Ramasamy Raveendran1, Mehdi Shafiee Ardestani2, Ananthakrishnan Ramesh3, Ali Jabbari-Arabzadeh2, Mohammad Shafiee Alavidjeh2, Mohammad Reza Aghasadeghi2, Sundararajan Elangovan3, Halanaik Dhanapathi4★ Corresponding author

    1. 1Departments of Pharmacology, Institute of Postgraduate Medical Education and Research, Pondicherry, India.
    2. 2Nanobiotechnology and Hepatitis B/AIDs, Pasteur Institute of Iran, Tehran, Iran.
    3. 3Radiodiagnosis and.
    4. 4Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

    CORRESPONDENCE

    Subramani Parasuraman

    Departments of Pharmacology, Institute of Postgraduate Medical Education and Research, Pondicherry, India.

    Received: 23-08-2011; Revised: 05-10-2011.

    Volume 8, Issue 30 · pp. 129–134 · PUBLISHED 23 May 2012 · DOI: 10.4103/0973-1296.96559

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Aim: To determine the biodistribution properties of cleistanthin A and cleistanthin B in rodents using magnetic resonance imaging (MRI). Materials and Methods: Cleistanthins A and B, constituents of Cleistanthus collinus Roxb., were labelled with gadolinium (Gd3+) directly and injected into normal and tumoric nude mice. The tissue signal intensity was measured using MRI to perform a noninvasive kinetic assay. Wistar rats were used for determination of the grayscale intensity to observe the distribution patterns of of cleistanthins A and B. Results: Cleistanthin A is kinetically more attractive to the gastrointestinal tract than is cleistanthin B, which gets accumulated in muscular tissues of mice in greater concentrations compared with cleistanthin A. Cleistanthin B but not cleistanthin A showed tumoric affinity and exhibited a tumor kinetic attraction in tumoric mice. In rats, cleistanthin A showed greater grayscale intensities in the brain, liver, and skeletal muscles in immediate post contrast MRI images, whereas the gadolinium tagged cleistanthin B showed higher grayscale intensities in the cardiac muscle and skeletal muscles in delayed post contrast MRI images. Conclusions: Cleistanthin A is more pharmacokinetically attractive to the gastrointestinal tract than cleistanthin B.

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      Parasuraman, S., Raveendran, R., Ardestani, M. S., Ramesh, A., Jabbari-Arabzadeh, A., Alavidjeh, M. S., Aghasadeghi, M. R., Elangovan, S., & Dhanapathi, H. (2012). Biodistribution properties of cleistanthin A and cleistanthin B using magnetic resonance imaging in a normal and tumoric animal model. Pharmacognosy Magazine, 8(30), 129–134. https://doi.org/10.4103/0973-1296.96559