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    Article

    Cestocidal Activity of Acacia caesia stem bark on Raillietina echinobothrida

    K. Lalchhandama1★★ Corresponding author

    1. 1Department of Zoology, Pachhunga University College, Mizoram University, Aizwal 796001, India.

    CORRESPONDENCE

    K. Lalchhandama

    Akkiraju SudheerDepartment of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Chiyyedu, Anantapuram, Andhra Pradesh, INDIA.

    sudheerlegend@gmail.com

    Received: 14-05-2009; Revised: 02-06-2009; Accepted: 02-06-2009.

    Volume 1, Issue 4 · pp. 179–184 · PUBLISHED Jul-Aug 2009 · DOI:

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    The effects of the methanol extract of Acacia caesia Linnaeus (Mimosaceae) stem bark were examined on the avian gastrointestinal cestode, Raillietina echinobothrida Megnin. In vitro treatments of the cestodes with different concentrations, viz, 0.5, 1, 2, 5, 10, and 20 mg ml-1, of the plant extract indicated that the plant extract caused dose-dependent paralytic and mortality effects similar to that of albendazole, with significant mortality (P < 0.05) when compared to the control. However, the plant extract showed significant lethal effect only at the higher concentrations such as 5, 10, and 20 mg ml-1 while albendazole was effective at all concentrations tested. Scanning electron microscopy of the cestode treated with 20 mg ml-1 of the plant extract showed profound morphological alterations which were the deliberate hallmark effects of anthelmintic drugs. Devastating obliteration of tegumental surface, focal erosion and degeneration of the microtriches of the proglottids, and distortion of suckers on the scolex were clearly discernible. The plant extract thus showed profound anthelmintic effects and apparently acted trans-tegumentally to cause morphological damages.

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      Lalchhandama, K. (2009). Cestocidal Activity of Acacia caesia stem bark on Raillietina echinobothrida. Pharmacognosy Research, 1(4), 179–184.