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    Article

    Modulatory Effect of Erythrina vareigata on Experimental Hyperlipidaemia in Male Wistar Rats

    K Mangathayaru1★, K Balakrishna2, Kuruvilla Sarah3, Reddy C Uma Maheshwara1★ Corresponding author

    1. 1*Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai – 600 116, India
    2. 2aCaptain Srinivasa Murty Drug Research Institute for Ayurveda and Siddha, Chennai – 600 106, India.
    3. 3bSri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai – 600 116, India.

    CORRESPONDENCE

    K Mangathayaru

    Phone: 044 24768403

    kvmanga@yahoo.com

    Received: 25-04-2009; Revised: 02-06-2009; Accepted: 09-06-2009.

    Volume 1, Issue 4 · pp. 202–207 · PUBLISHED Jul-Aug 2009 · DOI:

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Erythrina vareigata is a medium sized quick growing tree found distributed in deciduous forests throughout India. Its leaves are eaten as a pot herb and different parts of the plant have folkloric reputation as an anti inflammatory in India, China and South east Asia. Bark, wood, root and flowers are richly represented by isoflavones, pterocarpans and biphenyls. Current investigations were aimed at evaluating the hypolipidaemic activity of this popular hypolipidaemic siddha drug. Its nutritive value was estimated by standard reported methods. Ethyl acetate extract of the dried leaves were analyzed for total phenol content by Folin Ciocalteau and Titanium tetrachloride method. Its in vitro anti oxidant activity was assessed by DPPH, NO and trichloroacetic acid based reducing power method. Male wistar rats were subjected to high fat diet induced (HFD) hyperlipidaemia concurrent with extract administration for 60 days. While normal control group received standard pellet diet, Positive control group was on HFD only. At the end of experimentation, blood was collected for serum estimation of total cholesterol, high density lipoprotein cholesterol, triglycerides and atherogenic index. The extract had a high total phenol content, beneficially altered lipid parameters and reduced body weight of experimental animals. The leaves are rich in protein, minerals, vitamins and low in carbohydrate and fat. Anti oxidant activity of the polyphenols present in the extract might be mediating the observed hypoplipidaemia. This study validated the traditional medicine claims of its anti obesity effect as well as folkloric tutelage of consumption of leaves as a green vegetable.

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      Mangathayaru, K., Balakrishna, K., Sarah, K., & Maheshwara, R. C. U. (2009). Modulatory Effect of Erythrina vareigata on Experimental Hyperlipidaemia in Male Wistar Rats. Pharmacognosy Research, 1(4), 202–207.