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    Article

    Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis

    B. Villaflores Oliver1, G. Macabeo Allan Patrick1, Gehle Dietmar2, Krohn Karsten2, G. Franzblau Scott3, M. Aguinaldo Alicia1★★ Corresponding author

    1. 1Phytochemistry Laboratory, Research Center for the Natural Sciences, Thomas Aquinas Research Complex, University of Santo Tomas, España, Manila 1015 Philippines
    2. 2University of Paderborn, Department of Chemistry, Warburgerstrasse 100, 33098 Paderborn, Germany
    3. 3Institute for TB Research, College of Pharmacy, MC 964 Rm 412, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612-7231 U.S.A.

    CORRESPONDENCE

    M. Aguinaldo Alicia

    alicia_a8@yahoo.com, Tel/fax +(63 2) 731-5728

    amaguinaldo@mnl.ust.edu.ph

    Received: 31-07-2009; Revised: 15-08-2009; Accepted: 15-08-2009.

    Volume 1, Issue 5 · pp. 261–269 · PUBLISHED Sep-Oct 2009 · DOI:

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Alpinia purpurata or red ginger was studied for its phytochemical constituents as part of our growing interest on Philippine Zingiberaceae plants that may exhibit antimycobacterial activity. The hexane and dichloromethane subextracts of the leaves were fractionated and purified using silica gel chromatography to afford a mixture of C28 to C32 fatty alcohols, a 3-methoxyflavone and two steroidal glycosides. The two latter metabolites were spectroscopically identified as kumatakenin (1), sitosteryl-3-O-6- palmitoyl-β-D-glucoside (2) and β-sitosteryl galactoside (3) using UV, IR, EIMS and NMR experiments, and by comparison with literature data. This study demonstrates for the first time the isolation of these constituents from A. purpurata. In addition to the purported anti-inflammatory activity, its phytomedicinal potential to treat tuberculosis is also described.

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      Oliver, B. V., Patrick, G. M. A., Dietmar, G., Karsten, K., Scott, G. F., & Alicia, M. A. (2009). Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis. Pharmacognosy Research, 1(5), 261–269.