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    Beneficial Effects of Caesalpinia digyna Extract against acid Aspiration‑Induced Acute Lung Injury in Mice

    Manju Chaudhary1, Pratibha Sharma1, Meenu Mittal1, Rajneet Kaur1, Vivek Dharwal1, Ashwani Kumar2, Amarjit Singh Naura1★★ Corresponding author

    1. 1Department of Biochemistry, Panjab University, INDIA.
    2. 2University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, INDIA.

    CORRESPONDENCE

    Amarjit Singh Naura

    Department of Biochemistry, Panjab University, INDIA.

    anaura@pu.ac.in

    Volume 10, Issue 3 · pp. 243–249 · PUBLISHED · DOI: 10.4103/pr.pr_4_18

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Objective:Caesalpinia digyna belongs to the genus Caesalpinia, which is known since ancient times for its medicinal properties. The present work was designed to evaluate the beneficial potential of hydroalcoholic extract of the roots of C. dignea against hydrochloric acid (HCl)‑induced acute lung injury in mice. Materials and Methods:Ethanolic extract of C. dignea roots at a dose of 50, 100, or 200 mg/kg boy weight was given once orally 90 min before HCl administration. Mice were then analyzed for infiltration of inflammatory cells in bronchoalveolar lavage fluid (BALF) and oxidative stress markers in the lung tissue. Further, the effects of the extract were compared with bergenin isolated from the extract. Results: Our results showed that an oral administration of the extract 90 min before HCl instillation reduced the infiltration of neutrophils in the lungs in a dose‑dependent manner. Reduction in lung inflammation was associated with decline in pulmonary edema as the total protein content in the BALF was found to be decreased substantially. The drug also restored the redox balance in the lungs toward normal on HCl treatment as assessed by measuring the levels of reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), and catalase activity. Bergenin, isolated from the plant, was able to suppress the neutrophils but increased the macrophage number in BALF when administered before HCl instillation, suggesting immunoregulatory properties of the key constituent of the extract. Conclusion:Our data suggest that hydroalcoholic extract of Caesalpinia digyna roots constitute the phytochemicals that can protect against HCl‑induced acute lung injury in mice.

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      Chaudhary, M., Sharma, P., Mittal, M., Kaur, R., Dharwal, V., Kumar, A., & Naura, A. S. (). Beneficial Effects of Caesalpinia digyna Extract against acid Aspiration‑Induced Acute Lung Injury in Mice. Pharmacognosy Research, 10(3), 243–249. https://doi.org/10.4103/pr.pr_4_18