Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Seabuckthorn (Hippophae rhamnoides and Hippophae salicifolia) Seed Oil in Combating Inflammation: A Mechanistic Approach

    Suchita Dubey1, M. V. Ramana1, Anuradha Mishra2, Pushpraj S. Gupta3, Himani Awasthi1★★ Corresponding author

    1. 1Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Lucknow Campus, INDIA.
    2. 2Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, INDIA.
    3. 3Department of Pharmacy, Faculty of Health and Allied Sciences, SHIATS, Formerly Allahabad Agricultural University, Allahabad, Uttar Pradesh, INDIA.

    CORRESPONDENCE

    Himani Awasthi

    Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Lucknow Campus, INDIA.

    hawasthi@lko.amity.edu

    Volume 10, Issue 4 · pp. 404–407 · PUBLISHED · DOI: 10.4103/pr.pr_71_18

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Objective:This study assessed and comparedin vivoanti‑inflammatory activity of Hippophae rhamnoides (HR) andHippophae salicifolia (HS) seed oil. Materials and Methods:HR and HS seed oil was extracted by Soxhlet apparatus and characterized using gas chromatography mass spectroscopy. Wistar rats were used for predicting anti‑inflammatory activity. Results:HR and HS (2 and 4 ml/kg, respectively) exhibited dose‑dependent inhibition of carrageenan‑, histamine‑, prostaglandin‑, bradykinin‑, and arachidonic acid (AA)‑induced paw edema. Significant leukotriene‑induced inhibition was observed in HR. Myeloperoxidase (MPO) and lipid‑peroxidase (LPO) assays were performed and HR and HS seed oil significantly decreased the level of MPO and LPO at 4 ml/kg dose (P< 0.001). Conclusion:Dual inhibition of AA metabolism in HR and cyclooxygenase inhibition in HS was observed that might be attributed to the presence of polyunsaturated fatty acids (PUFAs), specifically, a correct balance of n‑3 and n‑6 PUFAs. However, the findings should be interpreted in the light of limitation of this study. Detailed experimentation at enzymatic levels would further help in substantiating the results inferred in this study.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Dubey, S., Ramana, M. V., Mishra, A., Gupta, P. S., & Awasthi, H. (). Seabuckthorn (Hippophae rhamnoides and Hippophae salicifolia) Seed Oil in Combating Inflammation: A Mechanistic Approach. Pharmacognosy Research, 10(4), 404–407. https://doi.org/10.4103/pr.pr_71_18