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    Mitochondrial Nephrotoxicity induced by Tacrolimus (FK‑506) and Modulatory Effects of Bacopa monnieri (Farafakh) of Tabuk Region

    Atif Abdulwahab A Oyouni1★, Shalini Saggu1, Ehab Tousson2, Anand Mohan3, Abdullah Farasani4★ Corresponding author

    1. 1Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, SAUDI ARABIA.
    2. 2Department of Zoology, Faculty of Sciences, Tanta University, Tanta, EGYPT.
    3. 3Department of Botany, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, INDIA.
    4. 4Department of Medical Laboratory, Faculty of Applied Medical Sciences, Jazan University, Jazan, SAUDI ARABIA.

    CORRESPONDENCE

    Atif Abdulwahab A Oyouni

    Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, SAUDI ARABIA.

    a.oyouni@ut.edu.sa

    Volume 11, Issue 1 · pp. 20–24 · PUBLISHED · DOI: 10.4103/pr.pr_100_18

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: Tacrolimus is a known immunosuppressive drug used widely for organ transplantation, but its nephrotoxicity mechanism is still unclear. Objectives: The present study investigates the protective efficacy of Bacopa monnieri (BM), against tacrolimus‑induced nephrotoxicity in rats. Materials and Methods:Group 1 (control group); administered orally with normal saline for 30 days; Group 2 (BM extract treated group); Group 3 (tacrolimus‑treated group); and Group 4; (tacrolimus plus BM extract treated group). Tacrolimus‑treated rats received 1 mg/kg body weight of tacrolimus intraperitoneally for 30 days, and BM‑pretreated rats were administered with the dose of 200 mg/kg orally by gavage once a day for 30 days. Results: Tacrolimus‑induced nephrotoxicity was assessed biochemically and histopathologically. Pretreatment with BM has shown to possess a significant protective effect against tacrolimus‑induced kidney functions regarding urea, creatinine, and albumin levels, respectively. The creatinine, mitochondrial lipid peroxidation (thiobarbituric acid reactive substances), and protein carbonyl levels were significantly increased dramatically, and however, the total proteins, albumin, glutathione, superoxide dismutase, and glutathione peroxidase were decreased when pretreated with tacrolimus. The nephroprotective efficacy of the BM extract was further evident by histopathological analysis and DNA fragmentation. Conclusion: The outcome of this study indicates that BM extracts exerted protection against tacrolimus‑induced kidney toxicity.

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      Oyouni, A. A. A., Saggu, S., Tousson, E., Mohan, A., & Farasani, A. (). Mitochondrial Nephrotoxicity induced by Tacrolimus (FK‑506) and Modulatory Effects of Bacopa monnieri (Farafakh) of Tabuk Region. Pharmacognosy Research, 11(1), 20–24. https://doi.org/10.4103/pr.pr_100_18