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    In silico Anti‑Preeclampsia Potential of Phytochemical Found in Ficus elastica

    Chrismis Novalinda Ginting1★, I Nyoman Ehrich Lister2, Ermi Girsang1, Yolanda Eliza Putri3, Maya Sari Mutia3, Riastawaty Purba4, Wahyu Widowati5, Satrio Haryo Benowo Wibowo6, Rizal Rizal6★ Corresponding author

    1. 1Department of Public Health, Faculty of Medicine, University of Prima Indonesia, Medan, INDONESIA.
    2. 2Department of Biomedical Science, Faculty of Medicine, University of Prima Indonesia, Medan, INDONESIA.
    3. 3Department of Medical Science, Faculty of Medicine, University of Prima Indonesia, Medan, INDONESIA.
    4. 4Department of Midwifery, Faculty of Health Science and Pharmacy, Adiwangsa Jambi University, Jambi, INDONESIA.
    5. 5Medical Research Center, Faculty of Medicine, Maranatha Christian University, Bandung, INDONESIA.
    6. 6Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, INDONESIA.

    CORRESPONDENCE

    Chrismis Novalinda Ginting

    Department of Public Health, Faculty of Medicine, University of Prima Indonesia, Medan, INDONESIA.

    chrismis@unprimdn.ac.id

    Volume 11, Issue 3 · pp. 279–282 · PUBLISHED · DOI: 10.4103/pr.pr_176_18

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Context: Preeclampsia (PE) is a disorder found in pregnant women characterized by high blood pressure and high protein content in urine. Delivery of the baby and placenta is the most recommended treatment in PE, but treating its symptoms (hypertension) has also been recommended.Aims:This study is intended to assess the major compounds found in Ficus elastica leaf as anti‑PE using an in silico approach. Settings and Design: All in silico analysis was performed under default settings. Subjects and Methods: Antioxidant and anti‑inflammatory probability values of the five compounds in F. elastica leaf are predicted using quantitative structure–activity relationship. The possible binding mode of the compounds is predicted using molecular docking.Results:Based on the structural properties, compounds found in F. elastica leaf have a high probability activity as an antioxidant and anti‑inflammatory. The compounds found in F. elastica, especially morin, have the highest binding affinity toward beta‑adrenergic receptor 2 (ADRB2) with similar intermolecular interaction with its known inhibitor. Conclusions: The compounds found in F. elastica may be beneficial for treating PE through its possible antioxidant and anti‑inflammatory properties and inhibition of ADRB2. Key words: Ficus elastica, hypertension, molecular docking.

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      Ginting, C. N., Lister, I. N. E., Girsang, E., Putri, Y. E., Mutia, M. S., Purba, R., Widowati, W., Wibowo, S. H. B., & Rizal, R. (). In silico Anti‑Preeclampsia Potential of Phytochemical Found in Ficus elastica. Pharmacognosy Research, 11(3), 279–282. https://doi.org/10.4103/pr.pr_176_18