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    Carqueja (Baccharis trimera) Essential Oil Chronic Treatment Induces Ventricular Repolarization Disorder in Healthy Rats but Not in Type 2 Diabetic Rats

    Alice Pereira Duque1, Carole Sant'ana Massolar1, Cristiane Barbosa Rocha2, Ana Paula Machado Da Rocha1, Ricardo Felipe Alves Moreira3, Luiz Fernando Rodrigues Junior4

    1. 1Department of Physiological Sciences, Cardiovascular Biophysics Laboratory, Federal University of The State of Rio De Janeiro, Rio De Janeiro, BRAZIL.
    2. 2Department of Physiological Sciences, Laboratory of Medicinal Herb Studies, Federal University of The State of Rio De Janeiro, Rio De Janeiro, BRAZIL.
    3. 3Department of Collective Health, Laboratory of Food Composition and Aroma Studies, Federal University of The State of Rio De Janeiro, Rio De Janeiro, BRAZIL.
    4. 4Department of Physiological Sciences, Cardiovascular Biophysics Laboratory, Federal University of The State of Rio De Janeiro; Department of Education and Research, National Institute of Cardiology, Rio De Janeiro, BRAZIL.

    Volume 11, Issue 4 · pp. 410–413 · PUBLISHED · DOI: 10.4103/pr.pr_54_19

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease (CVD) development. The pharmacological treatment of T2DM can increase cardiovascular risk in diabetic patients. Carqueja (Baccharis trimera) is an antioxidant and hypoglycemic medicinal plant with promising action for T2DM non-pharmacological treatment. Objectives: The objective of this study is to investigate carqueja essential oil safety on the cardiovascular system of diabetic and non-diabetic rats. Materials and Methods:Four experimental groups were used to analyze the carqueja essential oil effects: control group (n = 5), carqueja‑treated control group (n = 4), diabetic control group (n = 4), and carqueja‑treated diabetic group (n = 5). T2DM was induced by hypercaloric diet followed by streptozotocin administration. Electrocardiogram parameters were used to analyze the alterations in the cardiovascular system. Results: Diabetic rats showed ventricular repolarization dysfunction with prolongation of QT and corrected QT intervals. The treatment increased ventricular repolarization duration in the control group. Conclusion:Carqueja essential oil treatment worsens ventricular repolarization in nondiabetic rats, increasing the arrhythmogenic risk.

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      Duque, A. P., Massolar, C. S., Rocha, C. B., Rocha, A. P. M. D., Moreira, R. F. A., & Junior, L. F. R. (). Carqueja (Baccharis trimera) Essential Oil Chronic Treatment Induces Ventricular Repolarization Disorder in Healthy Rats but Not in Type 2 Diabetic Rats. Pharmacognosy Research, 11(4), 410–413. https://doi.org/10.4103/pr.pr_54_19