Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Ulcerative Colitis Induced with Acetic Acid is Ameliorated by Antrocaryon micraster through Reduced Serum Levels of Tumor Necrosis Factor Alpha and Interleukin‑6 in Sprague Dawley Rats

    Leslie Brian Essel1, David Darko Obiri2, Newman Osafo2★, Aaron Opoku Antwi2, Moses Babatunde Duduyemi3★ Corresponding author

    1. 1Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA; Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri, Kansas City, Missouri, USA.
    2. 2Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA.
    3. 3Department of Pathology, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA.

    CORRESPONDENCE

    Newman Osafo

    Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GHANA.

    nosafo.pharm@knust.edu.gh

    Volume 12, Issue 1 · pp. 85–91 · PUBLISHED · DOI: 10.4103/pr.pr_75_19

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: Antrocaryon micraster possesses significant antioxidant and anti‑inflammatory activities. These properties are shared by medicinal plants that have demonstrated beneficial effects in the treatment of ulcerative colitis. Objectives: To assess the effect of the total ethanol stem bark ofA. micrasterextract (AME) on damage to the rat colon in acetic acid‑induced colitis. Materials and Methods:Rats were pretreated with sulphasalazine 500 mg/kg or AME 30, 100, and 300 mg/kg daily for 3 days after which colitis was induced in test animals with acetic acid (4% V/V). Rats were sacrificed 24 h later and blood samples were obtained for hematological and cytokine assays. Colons were dissected for assessment of macroscopic and microscopic damage. Results: AME treatment modified hematological parameters and reduced serum levels of tumor necrosis factor alpha and interleukin‑6. Macroscopic assessment showed that AME reduced mucosal erythema, edema, erosions, bleeding, and ulceration. Histology showed preserved mucosal architecture, reduced inflammatory cell infiltration, decreased mucosal thickening, preserved goblet cell numbers, and inhibition of mast cell proliferation and degranulation in the colons. Conclusion:Taken together, the total ethanol stem bark AME exerts ameliorative effects on damage to the rat colon in acetic acid‑induced colitis.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Essel, L. B., Obiri, D. D., Osafo, N., Antwi, A. O., & Duduyemi, M. B. (). Ulcerative Colitis Induced with Acetic Acid is Ameliorated by Antrocaryon micraster through Reduced Serum Levels of Tumor Necrosis Factor Alpha and Interleukin‑6 in Sprague Dawley Rats. Pharmacognosy Research, 12(1), 85–91. https://doi.org/10.4103/pr.pr_75_19