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    Antidiabetic and Antidyslipidemic Activities of Hexane/Ethyl Acetate/Methanol Fractions of Paspalum scrobiculatum Linn. Grains in High‑Fat Diet and Streptozotocin‑Induced Diabetic Rats

    G Jyothi Reddy1★, K Bhaskar Reddy2, G V Subba Reddy3★ Corresponding author

    1. 1Department of Pharmaceutical Sciences, JNTUA, Ananthapuramu, INDIA.
    2. 2Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, INDIA.
    3. 3Department of Chemistry, JNTUA College of Engineering, Pulivendula, Andhra Pradesh, INDIA.

    CORRESPONDENCE

    G Jyothi Reddy

    Department of Pharmaceutical Sciences, JNTUA, Ananthapuramu, INDIA.

    jyothi.reddy992@gmail.com

    Received: 08-02-2020; Revised: 15-04-2020; Accepted: 17-04-2020.

    Volume 12, Issue 3 · pp. 230–235 · PUBLISHED · DOI: 10.4103/pr.pr_6_20

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: Dietary habits and sedentary lifestyle are the major causes of increasing obesity, which in turn causes diabetes and cardiovascular problems. With this alarming increase, there is a need for alternative therapies to treat diabetes and hyperlipidemia. Objectives: To evaluate antidiabetic and antidyslipidemic effects of fractions of Paspalum scrobiculatum grains in rats. Materials and Methods: Different doses of Hexane: Ethyl acetate fraction of P. scrobiculatum (HEPS) and Ethyl acetate: Methanol fraction ofP. scrobiculatum (EMPS) fractions of P. scrobiculatumwere administered to the high‑fat diet (HFD) and streptozotocin (STZ) (35 mg/ kg)‑induced diabetic rats with glibenclamide at 20 mg/kg body weight (b.w) as a standard reference. Biochemical and histopathological changes were assessed after 5 weeks of treatment. Results: Daily oral treatment with HEPS and EMPS each at 100 and 200 mg/kg b.w for 5 weeks was found to be significant in the reduction of plasma glucose levels, HbA1c, increased plasma insulin levels, and normalized lipid profile and liver function parameters in HFD and STZ‑induced diabetic rats. In addition, degenerative histopathological changes seen in liver, kidney, and pancreas of diabetic rats were found to be normalized in HEPS and EMPS as comparable to that of glibenclamide‑treated rats. Conclusion: The obtained results suggest that HEPS and EMPS fractions of P. scrobiculatumgrains possess promising antihyperglycemic and antidyslipidemic potential without apparent toxic effects, which may prove the claimed use of the plant in treatment of diabetes and dyslipidemia.

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      Reddy, G. J., Reddy, K. B., & Reddy, G. V. S. (). Antidiabetic and Antidyslipidemic Activities of Hexane/Ethyl Acetate/Methanol Fractions of Paspalum scrobiculatum Linn. Grains in High‑Fat Diet and Streptozotocin‑Induced Diabetic Rats. Pharmacognosy Research, 12(3), 230–235. https://doi.org/10.4103/pr.pr_6_20