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    In silico Investigation on Phytoconstituents in Pamburus missionis S. for Antioxidant Activity

    Raveesha Peeriga1★, Keerthi Priyanka Adarapu1, Akhila Kurama1, Naseemunnisa Mohammed1, Lakshmana Rao Atmakuri1, Deepak Kumar2★ Corresponding author

    1. 1Department of Pharmacognosy, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.
    2. 2Department of Pharmacognosy, Ranchi College of Pharmacy, Ranchi, Jharkhand, INDIA.

    CORRESPONDENCE

    Raveesha Peeriga

    Department of Pharmacognosy, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.

    drprsha@gmail.com

    Received: 30-03-2022; Revised: 22-04-2022; Accepted: 06-06-2022.

    Volume 14, Issue 3 · pp. 246–250 · PUBLISHED · DOI: 10.5530/pres.14.3.35

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Pamburus missionisis geographically originated from southern India and it has been used for ailments. Objectives:This current research was performed to analyze in silico evaluation of phytoconstituents present in Pamburus missionis for antioxidant activity. Materials and Methods:In silicoactivity of the isolated constituents for antioxidant activity was carried out by Autodock 4.0 and absorption, distribution, metabolism, excretion/toxicity assessed by online tools. Results:The results revealed that the phytocompounds, benzoic acid 2,3-dimethyl showed the good docking score of -5.8 kcal/mol, which was a mere docking score of standard curcumin, i.e., -6.6 kcal/mol hence proving that a good binding compatibility among the ligand and the receptor site NADPH oxidase. The Absorption, distribution, metabolism, excretion/toxicity evaluation of phytoconstituents assures that they had obeyed Lipinski’s guideline of five suggesting their safety consumption. Conclusion:To conclude, Pamburus missionis can be a good resource of antioxidant activity and simulation studies is needed to ensure the antioxidant activity of benzoic acid 2,3-dimethyl.

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      Peeriga, R., Adarapu, K. P., Kurama, A., Mohammed, N., Atmakuri, L. R., & Kumar, D. (). In silico Investigation on Phytoconstituents in Pamburus missionis S. for Antioxidant Activity. Pharmacognosy Research, 14(3), 246–250. https://doi.org/10.5530/pres.14.3.35