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    A New Cytotoxic Ceramide from Dalbergia boehmii Taub. Stem Bark Articles

    Jean Pierre Abdou1,2★, Jean Noël Nyemb3, Jean Momeni1, Atikou Fadimatou1, Abel Joël Yaya Gbaweng1, Jean Paul Tsopmejio4, Guidawa Fawa5, Muhammad I. Choudhary6★ Corresponding author

    1. 1Department of Chemistry, Faculty of Science, University of Ngaoundere, Ngaoundere 454, CAMEROON.
    2. 2Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaounde, CAMEROON.
    3. 3Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Kaele, CAMEROON.
    4. 4Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde, CAMEROON.
    5. 5Department of Biological Science, Faculty of Science, University of Ngaoundere, Ngaoundere, CAMEROON.
    6. 6H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, PAKISTAN.

    CORRESPONDENCE

    Jean Pierre Abdou

    Department of Chemistry, Faculty of Science, University of Ngaoundere, Ngaoundere 454, CAMEROON.

    abdoujeanpierre1@yahoo.fr

    Received: 19-07-2022; Revised: 29-08-2022; Accepted: 05-09-2022.

    Volume 14, Issue 4 · pp. 442–445 · PUBLISHED · DOI: 10.5530/pres.14.4.64

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Dalbergia boehmii(Leguminosae),is a medicinal plant used in the Northen part of Cameroon, against digestive tract diseases and fever. Objectives:This work which is part of the search for bioactive molecules through natural products, aimed to isolate, characterize and evaluate the cytotoxicity of compounds from D. boehmii. Materials and Methods:Chemical investigations were carrying out on stem barks of Dalbergia boehmiiusing chromatographic techniques. Structures elucidation of isolated compounds were done using 1D and 2D NMR as well as EI-MS and literature data. Some isolated compounds were evaluated in vitroagainst MCF-7 cell lines for their cytotoxicity activity, using the MTT colorimetric method. Results:The chemical investigation leaded to the isolation of a new ceramide derivative named Dalbergiamide (1), a triterpene identified as olean-12-ene-3,11-dione (2) isolated here for the first time from Dalbergiagenus, along with two known compounds, glucoside 3-O-β- D-sitosterol (3) and glucoside 3-O-β-D-stigmasterol (4). Compounds 1 and 2 were found to be cytotoxic at 50 μM with IC50 value of 17.13 μM and 35.52 ± 2.95 μM respectively. Conclusion:These promising results suggested more in-depth studies should be carried out on this plant in order to assess its potential in the fight against cancer.

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      Abdou, J. P., Nyemb, J. N., Momeni, J., Fadimatou, A., Gbaweng, A. J. Y., Tsopmejio, J. P., Fawa, G., & Choudhary, M. I. (). A New Cytotoxic Ceramide from Dalbergia boehmii Taub. Stem Bark Articles. Pharmacognosy Research, 14(4), 442–445. https://doi.org/10.5530/pres.14.4.64