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    Article

    In vitro Antioxidant Activity and Preliminary Phytochemical Evaluation of Different Extracts of Aerva javanica

    CK Thasneem1★, GR Vijayasankar2, BS Venkateswarlu2, R Margret Chandira2, S Shanmuganathan3★ Corresponding author

    1. 1Vinayaka Mission’s Research Foundation, Ariyanoor, Salem, Tamil Nadu, INDIA.
    2. 2Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Kondappanaickenpatti, Salem, Tamil Nadu, INDIA.
    3. 3Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, INDIA.

    CORRESPONDENCE

    CK Thasneem

    Vinayaka Mission’s Research Foundation, Ariyanoor, Salem, Tamil Nadu, INDIA.

    thasneeemck@gmail.com

    Received: 17-08-2022; Revised: 29-09-2022; Accepted: 05-10-2022.

    Volume 14, Issue 4 · pp. 468–473 · PUBLISHED · DOI: 10.5530/pres.14.4.68

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Ethno medicinal validation, together with the screening of phytochemical and biological activity, is an effective method for identifying new drugs from medicinal herbs. Objectives:The present study was aimed to investigate the phytochemical nature and antioxidant potential of the selected plant Aerva javanica.Materials and Methods:The plant material of A. javanicawas collected, authenticated, leaf and stem parts were separated, shade dried, powdered separately in to coarse powder and extracted with ethanol by Soxhlet apparatus. Both extracts (leaves and stem) were subjected to phytochemical evaluation, total phenolic content estimation by Folin-Ciocalteau and the total flavonoids content estimation by using aluminium chloride colorimetric method. In vitroantioxidant evaluation of the leaves and stem extracts were done by different approaches such as DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay, reducing power assay, superoxide and nitric oxide radical scavenging assays. Results:In the preliminary phytochemical analysis, both leaves and stem extract showed the presence of alkaloids, glycosides, tannins and phenolic compounds and flavonoids. The results showed the absence of carbohydrates, proteins and amino acids and sterols. The total phenolic content in the ethanol extract of A. javanicaleaves and stems were found to be 891mg/g and 841mg/g of extract equivalent to gallic acid. The total flavonoids content in the ethanol extract of A. javanicaleaves and stems were found to be 950mg/g and 900mg/g of extract equivalent to quercetin. The leaves extract showed maximum antioxidant activity comparing with stem extract in all the test approaches employed. Conclusion:The chromatographic and spectral studies and detailed pharmacological evaluation of the extracts may give more promising data.

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      Thasneem, C., Vijayasankar, G., Venkateswarlu, B., Chandira, R. M., & Shanmuganathan, S. (). In vitro Antioxidant Activity and Preliminary Phytochemical Evaluation of Different Extracts of Aerva javanica. Pharmacognosy Research, 14(4), 468–473. https://doi.org/10.5530/pres.14.4.68