Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Anti-spasmodic and Gastroprotective Activities of Harungana madagascariensis Leaf: A Traditional Anti-diarrhoea Remedy

    Adaobi C. Ezike1★, Nwoyi N. Bassey1, Emenike C. Amah1, Daniel U. Nwankpa1, Aniebiet E. Samuel1, John O. Medewase1★ Corresponding author

    1. 1Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu, NIGERIA.

    CORRESPONDENCE

    Adaobi C. Ezike

    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu, NIGERIA.

    adaobi.ezike@unn.edu.ng

    Received: 21-08-2022; Revised: 03-09-2022; Accepted: 21-09-2022.

    Volume 14, Issue 4 · pp. 492–498 · PUBLISHED · DOI: 10.5530/pres.14.4.71

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Harungana madagascariensisLam. ex Poir. (Hypericaceae) leaf extract is used by some communities in the Niger Delta to treat diarrhoea, ulcers, and wounds. Objectives:This study investigated the antispasmodic, antimotility and gastroprotective properties of methanol:dichloromethane (1:1) extract of H. madagascariensisleaves (HME). Materials and Methods:The antispasmodic activity was evaluated in vitrousing actions on contractions of guinea pig ileum and rabbit jejunum provoked by spasmogens. The actions of HME on gastrointestinal transit was assessed in vivousing normal defaecation and charcoal meal transit time tests in rodents. The actions of HME on gastric ulcers produced by ethanol and indomethacin were investigated. The HME was also subjected to phytochemical analysis and acute toxicity tests. Results:The HME suppressed contractions of isolated rabbit jejunum and guinea pig ileum elicited by histamine and acetylcholine. The extract elicited significant (P<0.05) reduction of normal defaecation (12.50 - 100%) and gastrointestinal propulsion of charcoal meal in mice (17.60 - 43.08%). Additionally, the extract significantly (P<0.05) prevented both ethanol- and indomethacin-induced stomach ulcers. An oral LD50 >5000 mg/kg in mice was obtained by an acute toxicity assay on HME. Conclusion:The findings showed that the leaf of H. madagascariensishas gastroprotective, antispasmodic, and antimotility properties.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Ezike, A. C., Bassey, N. N., Amah, E. C., Nwankpa, D. U., Samuel, A. E., & Medewase, J. O. (). Anti-spasmodic and Gastroprotective Activities of Harungana madagascariensis Leaf: A Traditional Anti-diarrhoea Remedy. Pharmacognosy Research, 14(4), 492–498. https://doi.org/10.5530/pres.14.4.71