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    Article

    Physiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches

    Poojashree Verma1, Neelesh Maheshwari2, Deepika Bairagee1★★ Corresponding author

    1. 1Faculty of Pharmacy, PAHER University, Udaipur, Rajasthan, INDIA.
    2. 2School of Pharmacy, Sangam University, Bhilwara, Rajasthan, INDIA.

    CORRESPONDENCE

    Deepika Bairagee

    Faculty of Pharmacy, PAHER University, Udaipur, Rajasthan, INDIA.

    bairagee.deepika@gmail.com

    Received: 26-08-2022; Revised: 15-09-2022; Accepted: 09-11-2022.

    Volume 15, Issue 1 · pp. 64–70 · PUBLISHED · DOI: 10.5530/097484900244

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Aim:The present research aimed to formulate a transdermal patch incorporating herbal bioactiveVitex negundoextract. The polymers that were used for selected sustained release of the drug are HPMC, PVP K30 and polyethylene glycol used as a plasticizer. Materials and Methods:Transdermal patches were prepared using the drug with two (HPMC and PVP K30) different polymers. The prepared transdermal films were evaluated for their physico-chemical characteristics such as physical appearance, weight uniformity, thickness, folding endurance, moisture content, drug content, percent moisture loss and permeation studies. The skin irritation study done on rat skin showed that the formulation does not produce irritation to the skin it showed the successful release of drug from the fabricated patch. Results:Thein vitro release of formulation F1, F2, F3, F4, F5 and F6 has shown release of about 89.15%, 87.12%, 82.34%, 92.45%, 86.78% and 76.21% at 8hr. The order of drug release was found to be F4>F1>F2>F3>F6>F5.Conclusion: It could be concluded that it was concluded from the study, that the transdermal patch containing herbal bioactiveVitex negundo F4 batch showed the highest percent of drug release and other desirable properties can be developed.

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      Verma, P., Maheshwari, N., & Bairagee, D. (). Physiochemical Characterization and in vitro Evaluation of Formulated Herbal Bioactive Loaded Transdermal Patches. Pharmacognosy Research, 15(1), 64–70. https://doi.org/10.5530/097484900244